Administrative Core

行政核心将主要负责项目管理和协调。虽然我们计划的各个组成部分在许多方面可以独立运作，但未来五年的成功在很大程度上取决于四个主要研究机构的研究人员之间的有效互动。因此，将不断需要保持开放的沟通渠道，并确保日常业务能够高效率和有效地进行。因此，本项目各组成部分的首席研究员也将为项目投入时间和精力

The Administration Core will have the primary responsibility for Program management and coordination. While the individual components of our Program can function independently in many respects, success during the next five years depends to a substantial degree on effective interactions among investigators at four major research institutions. Therefore, there will be constant needs to maintain open lines of communication, and to ensure that daily operations are carried out both efficiently and effectively. Thus, the Principal Investigator(s) of each component of our Program also will devote time and effort to program management and central coordination within the Administration Core. This will encourage our individual projects to continue to function as parts of a highly integrated whole. In addition, because our Aging Research Program has expanded to include other NIH funded projects as outlined in the introduction of this application, an aim of this Core will be to maintain collaborative relationships with these other efforts. These overall goals will be accomplished through: (a) management and coordination of program activities; (b) oversight of administrative requirements (e.g., coordination of IRB review and procedures for obtaining informed consents); (c) provision of statistical consultation to program investigators; (d) tracking of adverse events and developing necessary reports to oversight groups (e.g., IRBs at cooperating institutions, NIH), and (e) stimulation of productivity and dissemination of findings. An Advisory Committee will also be formed to review activities and progress and ensure that this program continues: (a) to meet its aims successfully, and (b) to retain its leadership role within this rapidly evolving field. The Committee will meet annually, and members will be available as needed should needs arise for additional advice.