Eunice Kennedy Shriver Intellectual and Developmental Disability Research Center

描述（由申请人提供）：范德比尔特肯尼迪人类发展研究中心（VKC），尤尼斯肯尼迪施莱佛智力和发育障碍研究中心（EKS-IDDRC），是在EKS NICHD的支持下的第44个年头。 VKC在过去五年中在其研究，服务和培训任务方面取得了显着增长。 从历史上看，VKC一直只是一个研究中心，但该中心的使命最近已扩大到包括研究，服务推广和培训。 2005年，VKC被授予发展障碍卓越大学中心（UCEDD），就在今年，神经发育障碍领导力教育（LEND）培训计划被行政分配给VKC。 IDDRC，UCEDD和LEND之间的协同互动导致了招募参与者，传播研究，培训新的IDD研究人员和进行转化研究的进展。 VKC的发展还体现在招聘了21名新的研究人员，并开发了最先进的P30核心，以支持扩展的基础和临床科学使命。 组织者建议76名VKC研究人员获得P30支持，用于91个基础和临床研究项目，在使用模型系统研究大脑发育，神经元通信机制以及细胞和功能大脑可塑性的基础研究人员与研究认知和语言发展，情绪调节以及残疾对家庭影响的临床研究人员之间取得平衡。 因此，VKC P30支持四个主要项目领域的研究：1）与典型和非典型发展相关的基本机制; 2）认知过程和干预; 3）心理健康和干预; 4）对家庭和社区的生活影响。 然而，越来越多的VKC研究人员跨越这些传统的界限，将认知和行为科学与神经科学和遗传学方法相结合，以检查自闭症谱系障碍;阅读，数学和语言障碍; Prader-Willi，Angelman，威廉姆斯和唐氏综合征; ADHD;精神病，抑郁症和焦虑症。 为了满足这些雄心勃勃的研究计划的需求，组织者提出了五个P30核心：（A）行政;（B）基础神经科学;（C）统计和方法学;（D）临床神经科学，以及（E）参与者招募和评估。 这些核心是生成和推进VKC的基础，临床和跨学科研究议程，同时也为VKC研究人员，家庭和学员创造了一个充满活力的互动环境。 相关性：大约五分之一的儿童有发育障碍，包括自闭症谱系障碍、学习和智力障碍、唐氏综合症、多动症和情绪障碍。 该中心为范德比尔特肯尼迪中心的调查人员提供尖端的研究服务，使他们能够对残疾的原因做出新的发现，以及如何最好地进行干预，以促进儿童和成人的成功结果。

DESCRIPTION (Provided by Applicant): The Vanderbilt Kennedy Center for Research on Human Development (VKC), a Eunice Kennedy Shriver Intellectual and Developmental Disability Research Center (EKS-IDDRC), is in its 44th year of support from EKS NICHD. The VKC has experienced remarkable growth in the last five years in its research, service, and training missions. Historically, the VKC has been solely a research center, but the Center's mission has recently expanded to include research, service-outreach, and training. In 2005, the VKC was awarded a University Center of Excellence in Developmental Disabilities (UCEDD), and just this year the Leadership Education in Neurodevelopmental Disabilities (LEND) training program was administratively assigned to the VKC. Synergetic interactions across the IDDRC, UCEDD, and LEND have led to advances in recruiting participants, disseminating research, training new IDD researchers, and conducting translational research. Growth of the VKC is also reflected in the recruitment of 21 new research faculty, and development of state-of-the-science P30 cores to support an expanded basic and clinical science mission. The organizers propose 76 VKC investigators receive P30 support for 91 projects that span both basic and clinical research, with a balance between basic researchers who use model systems to study brain development, mechanisms of neuronal communication, and cellular and functional brain plasticity, and clinical researchers who examine cognitive and linguistic development, emotional regulation, and the impact of disabilities on families. The VKC P30 thus supports research in four major program areas: 1) basic mechanisms associated with typical and atypical development; 2) cognitive processes and interventions; 3) mental health and interventions; and 4) life impact effects on families and communities. Increasingly, however, VKC investigators cross these traditional boundaries to integrate cognitive and behavioral science with neuroscience and genetic methods to examine autism spectrum disorders; reading, math, and language disabilities; Prader-Willi, Angelman, Williams, and Down syndromes; ADHD; psychosis, depression, and anxiety disorders. To meet the needs of these ambitious research programs, the organizers propose five P30 cores: (A) Administrative; (B) Basic Neuroscience; (C) Statistics and Methodology; (D) Clinical Neuroscience, and (E) Participant Recruitment and Assessment. These cores are generative and advance the basic, clinical, and interdisciplinary research agendas of the VKC, while also creating a vibrant, interactive environment for VKC investigators, families, and trainees. RELEVANCE: Approximately one in five children have a developmental disability, including autism spectrum disorders, learning and intellectual disabilities, Down syndrome, ADHD, and mood disorders. This Center provides cutting-edge research services to Vanderbilt Kennedy Center investigators that allows them to make new discoveries about the causes of disabilities, and how to best intervene to foster successful outcomes in children and adults.