UCLA Muscular Dystrophy Core Center

描述(由申请人提供)：加州大学洛杉矶分校的肌营养不良症核心中心由一群对退行性肌肉疾病的治疗方法发展感兴趣的科学家组成。该中心的目标是通过提供资源、试点资金和丰富的智力环境，促进研究进展，鼓励肌肉研究人员和相关学科的其他研究人员在校园内进行富有成效的互动，从而改善和促进肌营养不良症的发现和临床前测试过程。该中心的存在将吸引既是知名肌肉研究人员，也是那些以前没有进行过肌肉研究的科学家，并通过这种联系，为该小组增加新的专业知识和经验。这些核心将使用基于新的细胞分析和新的转基因小鼠模型的高通量和非侵入性分析。中心科学家正在使用的高通量和非侵入性策略传统上与肌肉疾病无关，因此可能会促进新的进步和治疗学的快速发展。该中心的成员反映了各种不同的科学专业知识，将促进这一努力。行政核心的目的是协调中心的活动并促进实现这些目标。 具体而言，行政核心的目标是：目标1：向中心的核心和所有活动提供行政支助。目标2：通过组织一系列研讨会、年度务虚会和网站维护等丰富活动，促进中心科学家之间的合作和鼓励核心技术的使用。目标3：监督试点和可行性项目的审查和资金筹措。目的4：促进来自营养不良研究人员社区的数据共享和使用，以便这些核心将为肌营养不良研究提供全国性的资源。

DESCRIPTION (provided by applicant): The Muscular Dystrophy Core Center at UCLA is comprised of a group of scientists interested in the development of therapeutics for degenerative muscle disease. The goal of the Center is to improve and facilitate the process of discovery and pre-clinical testing for muscular dystrophy by providing resources, pilot funding and an intellectually rich environment that promotes research progress and encourages productive interactions between muscle researchers and other researchers in related disciplines on campus. The existence of the Center will attract scientists that are both established muscle researchers and those that have not previously conducted muscle research and, with this association, add new expertise and experience to the group. The Cores will use high throughput and non-invasive analyses based on novel cellular assays and novel genetically modified mouse models. The high throughput and non-invasive strategies being used by Center Scientists are not traditionally associated with muscle disease and may thereby foster novel advancements and rapid development of therapeutics. The Center membership reflects a variety of different scientific expertise that will facilitate this endeavor. The aims of the Administrative Core are to coordinate the activities of the Center and to facilitate these goals. Specifically the Aims of the Administrative Core are: Aim 1: To provide administrative support to the Cores and all activities of the Center. Aim 2: To facilitate collaboration between Center Scientists and encouragement of Core usage by organizing enrichment activities such as a seminar series, annual retreat and maintenance of a website. Aim 3: To oversee review and funding of pilot and feasibility projects. Aim 4: To facilitate data sharing and use of the cores from the greater community of dystrophy researchers so that the cores will provide a national resource for muscular dystrophy research.