Delaware INBRE

描述(由申请人提供)：特拉华州INBRE更新提案的目标是通过扩大当前INBRE在建设全州生物医学研究能力方面的工作，向改善该州的医疗保健迈出又一重要的一步。该项目将继续加强牵头机构和伙伴机构的研究专长和基础设施。将继续进行三个研究主题。在目前的INBRE计划下开始的一项癌症计划，将专注于癌细胞的移动性、特定蛋白质在转移中的作用、DNA修复以及用于癌症治疗的生物材料。一项新的心血管项目将专注于心力衰竭的细胞外基质重塑和心脏组织工程的生物材料。一项新的神经科学计划将研究糖尿病患者学习和记忆、脊髓性肌萎缩和心血管自主神经功能的分子机制。提供资金，支持初级教师、博士后和研究生参与每个研究主题的研究项目。研究主题得到全州生物医学基础设施的支持，该基础设施是在当前的INBRE下开发的，但具有显著增强的生物信息学和集中的仪器核心。本科生研究和专业发展核心将为该州本科院校和社区学院的学生提供研究机会，从而培养在卫生保健行业寻求职业生涯的学生，并增强该州劳动力的技术知识。 公共卫生相关性(由申请者提供)：特拉华州INBRE专注于癌症、心脏病和神经科学的研究，这三个领域的疾病每年夺去数百万美国人的生命。该项目通过提供研究种子赠款来帮助有前途的科学家开始他们的研究生涯，这构成了未来研究的基础。特拉华州INBRE还帮助培养新一代健康研究人员，让本科生参与进来

DESCRIPTION (provided by applicant): The goal of the Delaware INBRE renewal proposal is to take another major step towards improving health care in the State by extending the work of the current INBRE in building a statewide biomedical research capability. The project will continue to strengthen the research expertise and infrastructure of the lead and partner institutions. Three research themes will be pursued. A cancer program, begun under the current INBRE, will focus on cancer cell mobility, the role of specific proteins in metastasis, DNA repair and biomaterials for use in cancer treatments. A new cardiovascular program will focus on extra-cellular matrix remodeling in heart failure and biomaterials for cardiac tissue engineering. A new neuroscience program will address molecular mechanisms of learning and memory, spinal muscular atrophy and cardiovascular autonomic nerve function in diabetes. Funds to support junior faculty, postdoctoral and graduate students engaged in the research projects within each research theme, are provided. The Research Themes are supported by a statewide biomedical infrastructure developed under the current INBRE, but with considerably enhanced Bioinformatics and Centralized Instrumentation Cores. An Undergraduate Research and Professional Development Core will provide research opportunities for students from the State's undergraduate institutions and community colleges, thereby developing a pipeline of students pursuing careers in the health care industry and enhancing the technical knowledge of the State's workforce. PUBLIC HEALTH RELEVANCE (provided by applicant): The Delaware INBRE is focused on research in cancer, heart disease and neuroscience, three areas where disease take the lives of millions of Americans each year. The project helps promising scientists to begin their research careers/by providing research seed grants, which form a foundation for future research. Delaware INBRE also helps to build a new generation of health researchers, by involving undergraduate