Claude D Pepper Older Americans Independence Center at Yale

耶鲁老年美国人独立中心（OAIC）成立于1992年，旨在继续为旨在提高独立性的老龄化研究提供知识领导和创新。我们的统一主题仍然是多因素老年健康状况的调查，包括单一的条件下产生的多个因素或影响多个结果域和多个条件同时发生。我们的前提是，老年人常见的健康状况是由多种诱发和沉淀因素共同发生决定的。这些条件和因素反过来又影响到一系列卫生领域。诱发因素可能是遗传、生理（损伤）、疾病或社会人口学水平，而促发因素可能是行为、环境、社会、医学或心理。耶鲁大学OAIC研究的区别在于，它的目的是同时调查多个因素之间的相互作用或干预，并测量条件或干预措施对一系列健康领域的影响。耶鲁大学OAIC的目的是：1）发展未来的老龄化/老年医学学术领导者的职业生涯;2）培训调查人员和方法学家设计，进行和分析多因素老年健康状况研究所需的技能; 3）开发设计和分析技术，用于进行多因素老年健康状况的研究; 4）制定招募和保留广泛老年人（包括少数民族）的战略，以OAIC研究; 5）从多因素研究的角度调查老年人健康状况的致病机制，并确定有效的治疗方法; 6）开发用于调查多因素老年健康状况和研究多种共存条件的老年人的结果措施;和7）促进与我们对多因素老年健康状况的关注相关的基础，转化和跨学科研究。Yale OAIC核心包括：1）领导/行政; 2）研究职业发展; 3）试点/探索; 5）生物统计学; 6）数据管理/信息学;和7）现场。在下一个周期的头几年，我们提议支助4个区域发展中心候选项目; 4个试点研究（包括2个由区域发展中心候选项目进行的研究）; 1个计算生物学发展研究; 14个外部供资项目。 整个程序

DESCRIPTION (provided by applicant): Established in 1992, the Yale Older Americans Independence Center (OAIC) seeks to continue providing intellectual leadership and innovation for aging research that aims to enhance independence. Our unifying theme remains the investigation of multifactorial geriatric health conditions, encompassing single conditions resulting from multiple contributing factors or affecting multiple outcome domains and multiple conditions occurring simultaneously. Our premise is that health conditions common in older adults are determined by the co-occurrence of multiple predisposing and precipitating factors. These conditions and factors, in turn, affect a range of health domains. The predisposing factors may be at genetic, physiologic (impairment), disease, or socio-demographic levels, while the precipitating factors may be behavioral, environmental, social, medical, or psychological. What distinguishes Yale OAIC research is that its purpose is to investigate the interactions among, or intervene on, multiple factors simultaneously and to measure the effect of conditions or interventions on a range of health domains. The Aims of the Yale OAIC are to: 1) develop the careers of future academic leaders in aging/geriatrics;2) train investigators and methodologists in the skills necessary to design, conduct, and analyze studies of multifactorial geriatric health conditions; 3) develop design and analytic techniques for conducting studies of multifactorial geriatric health conditions; 4) develop strategies for recruiting into, and retaining, a broad spectrum of older adults, including minorities, into OAIC studies; 5) investigate the causative mechanisms of, and identify effective treatments for, health conditions experienced by older adults from a multifactorial research perspective; 6) develop outcome measures for use in investigating multifactorial geriatric health conditions and for studying older adults with multiple coexisting conditions; and 7) facilitate basic, translational, and interdisciplinary research that connects to our focus on multifactorial geriatric health conditions. The Yale OAIC cores include: 1) Leadership / Administrative; 2) Research Career Development; 3) Pilot/Exploratory; 5) Biostatistics; 6) Data Management / Informatics; and 7) Field. For the first years of the next cycle, we propose to support 4 RCDC candidates; 4 pilot studies (including 2 by RCDC candidates); 1 computational biology development study; and 14 externally funded projects. PROGRAM AS A WHOLE