New England Primate Research Center Base Grant

这份续签申请要求为新英格兰灵长类研究中心(NEPRC)的多学科生物医学研究和资源计划的继续提供五年的资金。提出了详细的计划，以支持有价值的研究，这将有助于理解和解决人类健康问题 按照美国国立卫生研究院的要求，使用非人类灵长类动物。我们描述了合作的研究计划 NEPRC七个科学单位内的活动、核心服务和试点研究方案：行为 生物学、比较病理学、免疫学、微生物学、神经化学、灵长类资源和 肿瘤病毒学。这七个单位的研究活动和核心服务都集中在 关于主要的公共卫生挑战，主要是艾滋病的治疗和预防，病毒引起的癌症， 神经退行性疾病和毒瘾。研究项目的性质从根本上讲是 在某些情况下是基本的，在其他情况下是适用的。研究计划和支持服务也很高 协作性质的，通常涉及来自内部和 在NEPRC之外。由中国人民银行S基金资助的核心和服务活动目前 支持1,010万美元的NIH资助的研究，用于NIH内部的NEPRC调查人员，以及2.68亿美元的 NIH资助的研究提供给非NEPRC外部调查人员。此外，这项建议旨在(1) 增强S中心作为区域、国家和国际资源的协同能力， 通过提供专门的设施、设备和技术，联系和访问科学家 专门知识，(2)增加用于生物医学研究的非人类灵长类动物的可用性，(3)培训 青年调查人员；(4)提供行政、科学和灵长类资源基础设施 维护和运营一个中心所必需的。这份申请中还包括五年期 现代化计划。哈佛医学院新英格兰灵长类动物研究中心 由AAALAC国际认证。

This renewal application requests five years of funding for continuation of the multidisciplinary biomedical research and resource program at the New England Primate Research Center (NEPRC). Detailed plans are presented for the support of meritorious research which will contribute to the understanding and solution of human health problems using nonhuman primates, as mandated by NIH. We describe the research programs, collaborative activities, core services, and pilot research programs within seven scientific units at NEPRC: Behavioral Biology, Comparative Pathology, Immunology, Microbiology, Neurochemistry, Primate Resources, and Tumor Virology. The research activities and core services within these seven units are intently focused on major public health challenges, principally AIDS treatment and prevention, viral-induced cancer, neurodegenerative diseases, and drug addiction. The nature of the research program is fundamentally basic in some cases, applied in others. The research programs and support services are also highly collaborative in nature, usually involving contributions from multiple scientific units from within and outside NEPRC. The core and service activities funded by NEPRC?s base grant are currently supporting$10.1 million in NIH-funded research to intramural NEPRC investigators and $268 million in NIH-funded research to extramural nonNEPRC investigators. Additionally, this proposal seeks to (1) enhance the Center?s ability to serve as a regional, national and international resource for collaborative, affiliated and visiting scientists by providing specialized facilities, equipment and technological expertise, (2) enhance the availability of non-human primates for use in biomedical research, (3) train young investigators, and (4) provide the administrative, scientific and primate resources infrastructure necessary to maintain and operate a Center. Also included in this application is a five year Modernization Program. The New England Primate Research Center, Harvard Medical School, is fully accredited by AAALAC International.