New England Primate Research Center Base Grant

本更新申请要求为新英格兰灵长类动物研究中心（NEPRC）的多学科生物医学研究和资源计划的继续提供五年的资金。详细的计划是为了支持有价值的研究，这将有助于理解和解决人类健康问题 使用非人类灵长类动物，由NIH授权。我们描述的研究计划，合作 活动，核心服务，并在七个科学单位在NEPRC试点研究计划：行为 生物学、比较病理学、免疫学、微生物学、神经化学、灵长类动物资源和 肿瘤病毒学这七个单位的研究活动和核心服务是集中在 主要是艾滋病的治疗和预防、病毒引起的癌症、 神经退行性疾病和药物成瘾。研究项目的本质是 在某些情况下是基本的，在另一些情况下是应用的。研究计划和支持服务也很重要。 协作性质，通常涉及内部多个科学单位的贡献， 在NEPRC之外。由国家环境政策审查委员会资助的核心和服务活动？的基本补助金目前 支持NIH资助的1010万美元的研究，以内部NEPRC调查人员和2.68亿美元， NIH资助的研究，以校外nonNEPRC研究人员。此外，该提案旨在（1） 加强中心？作为区域、国家和国际资源， 通过提供专门设施、设备和技术， （2）提高非人灵长类动物在生物医学研究中的可用性，（3）培训 年轻的研究人员，以及（4）提供行政，科学和灵长类动物资源基础设施 需要维护和运营一个中心。在这个应用程序中还包括一个五年 现代化计划。哈佛医学院的新英格兰灵长类动物研究中心， 获得AAALAC International认证。

This renewal application requests five years of funding for continuation of the multidisciplinary biomedical research and resource program at the New England Primate Research Center (NEPRC). Detailed plans are presented for the support of meritorious research which will contribute to the understanding and solution of human health problems using nonhuman primates, as mandated by NIH. We describe the research programs, collaborative activities, core services, and pilot research programs within seven scientific units at NEPRC: Behavioral Biology, Comparative Pathology, Immunology, Microbiology, Neurochemistry, Primate Resources, and Tumor Virology. The research activities and core services within these seven units are intently focused on major public health challenges, principally AIDS treatment and prevention, viral-induced cancer, neurodegenerative diseases, and drug addiction. The nature of the research program is fundamentally basic in some cases, applied in others. The research programs and support services are also highly collaborative in nature, usually involving contributions from multiple scientific units from within and outside NEPRC. The core and service activities funded by NEPRC?s base grant are currently supporting$10.1 million in NIH-funded research to intramural NEPRC investigators and $268 million in NIH-funded research to extramural nonNEPRC investigators. Additionally, this proposal seeks to (1) enhance the Center?s ability to serve as a regional, national and international resource for collaborative, affiliated and visiting scientists by providing specialized facilities, equipment and technological expertise, (2) enhance the availability of non-human primates for use in biomedical research, (3) train young investigators, and (4) provide the administrative, scientific and primate resources infrastructure necessary to maintain and operate a Center. Also included in this application is a five year Modernization Program. The New England Primate Research Center, Harvard Medical School, is fully accredited by AAALAC International.