SPORE in Head and Neck Cancer

描述(由申请人提供)：匹兹堡大学，并建议在头颈癌方面开展一个专门的卓越研究项目(孢子)。匹兹堡头颈部孢子的总体目标是提高头颈部癌症的检测和治疗水平。孢子计划将包括四个头颈部癌症的转化性研究项目、两个研究核心、一个发展研究计划和一个职业发展计划。匹兹堡大学的头颈孢子将通过与基础、应用和临床科学的合作研究人员一起开展项目，使用跨学科的方法来实现其目标。它也是器官特有的，因为它的方法和所有项目都将测试关于头颈部癌症生物学、敏感性、检测或治疗的假设。头颈孢子的长期目标是根据转译研究项目的研究结果进行临床研究，作为改善被诊断为头颈癌的患者预后的基础。这四个主要项目包括：(1)Cyclin D1和XPD基因多态性是SCCHN的潜在危险因素；(2)靶向激活的STAT3在头颈癌中的作用；(3)基于野生型p53的SCCHN的辅助免疫治疗；(4)靶向SCCHN中的EGFR和GPCR信号转导。这两个研究中心将密切互动，协助主要研究项目、发展研究项目和职业发展调查人员开展转化型头颈癌研究。研究核心包括：(1)组织学/组织银行学和(2)生物统计学和信息学。头颈部孢子调查人员将共同努力，协同实现该计划的目标，并将与其他机构的孢子调查人员互动，以改善头颈部癌症患者的预后。

DESCRIPTION (provided by applicant): The University of Pittsburgh and proposes to conduct a Specialized Program of Research Excellence (SPORE) in Head and Neck Cancer. The overall goals of the Pittsburgh Head and Neck SPORE are to improve the detection, and treatment of head and neck cancer. The SPORE program will consist of four translational research projects in head and neck cancer, two research cores, a developmental research program and a career development program. The University of Pittsburgh Head and Neck SPORE will use an interdisciplinary approach to meet its objectives by carrying out projects with co-investigators in basic, applied and clinical science. It is also organ-specific in that its approach and all projects will test hypotheses about head and neck cancer biology, susceptibility, detection, or treatment. The long-term goal of the Head and Neck SPORE is to conduct clinical studies based on research results from the translational research projects, that will serve as the basis for improving the outcome of patients diagnosed with head and neck cancer. The four main projects include: (1) Cyclin D1 and XPD polymorphisms as potential risk factors of SCCHN; (2) Targeting Activated Stat3 in Head and Neck Cancer; (3) Wild Type p53-based Adjuvant Immunotherapy for SCCHN; and (4) Targeting EGFR and GPCR Signaling in SCCHN. The two research cores will interact closely to assist the main research projects, developmental research projects and the career development investigators in carrying out translational head and neck cancer research. The research cores include: (1) Histology/Tissue Banking and (2) Biostatistics and Informatics. The Head and Neck SPORE investigators will work together to synergistically achieve the goals of the program and will also interact with investigators from SPOREs at other institutions to improve the outcome of patients with cancer of the head and neck.