SOLUTION STRUCTURE OF SERINE-RICH DOMAIN FROM CRK-ASSOCIATED SUBSTRATE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 130cas(Crk相关底物)是一种停靠蛋白，参与了局部粘连和伴随的细胞信号的组装。它在细胞的黏附、迁移、存活、增殖以及致癌转化中起着生理调节作用。该分子由多个蛋白质相互作用基序组成，包括位于Crk和Src结合位点之间的富含丝氨酸的区域。本研究首次报道了Cas功能结构域的结构。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 130cas (Crk-associated substrate) is a docking protein that is involved in assembly of focal adhesions and concomitant cellular signaling. It plays a role in physiological regulation of cell adhesion, migration, survival, and proliferation, as well as in oncogenic transformation. The molecule consists of multiple protein-protein interaction motifs, including a serine-rich region that is positioned between Crk and Src-binding sites. This study reports the first structure of a functional domain of Cas.