PROTEOMICS SHARED RESOURCE

诺里斯棉花癌症中心蛋白质组学共享资源(PRSR)的使命是 为NCCC研究人员提供本地访问最先进的蛋白质组技术、科学咨询 用于实验设计、关于结果解释的咨询和辅助生物分析支持 以实惠的价格提供服务。 作为一个独立的NCCC共享资源，PRSR于2007年秋季完成了 从作为前分子生物学和蛋白质组学一部分提供有限蛋白质组服务的过渡 共享资源作为独立的核心设施全面独立运行。在这一过渡期间， PRSR在NCCC Rubin Building研究实验室获得了新装修的实验室空间， 对其质谱仪和液相色谱仪进行了现代化改造，并扩大了其 计算资源，任命蛋白质组学系招募Scott A.Gerber博士担任PRSR主任， 并扩展了其服务组合，包括蛋白质翻译后修饰分析和复合体 蛋白质混合物分析。这些努力总共代表着NCCC和NCCC承诺的280万美元 达特茅斯医学院将把现代蛋白质组学平台带到癌症中心 研究人员和整个大达特茅斯研究界。 在这个为期一年的过渡阶段，PRSR从9项NCCC研究中获得了12,700美元的退款 实验室，或设施总退款(14,600美元)的87%(来自达特茅斯大学的16个合计 实验室)。我们估计，2008财年(CCSG的第一年)PRSR的总运营成本 续订)将为326,760美元，预计总按存储容量使用计费为40,000美元，需要CCSG和 来自其他来源的238,411美元，用于NCCC调查人员(缺口的75%)。由于……的快速增长 过去一年对PRSR服务的需求，我们预计 PRSR使得NCCC和机构的大笔补贴可以减少。目前，支持资金用于 转型中的PRSR是由多种制度来源提供的。

The mission of the Proteomics Shared Resource (PRSR) at the Norris Cotton Cancer Center (NCCC) is to provide NCCC investigators with local access to state-of-the-art proteomic technologies, scientific consulting For experimental design, consultation regarding results interpretation, and ancillary bioanalytical support services at affordable rates. Newly established as an independent NCCC Shared Resource, the PRSR in Fall 2007 completed its transition from providing limited proteomic services as part of the former Molecular Biology and Proteomics Shared Resource to full-fledged independent operation as a stand-alone core facility. During this transition, the PRSR acquired newly renovated laboratory space in the NCCC Rubin Building research labs, modernized its mass spectrometry and liquid chromatography instrumentation and expanded its computational resources, appointed proteomics faculty recruit Dr. Scott A. Gerber as Director of the PRSR, and expanded its service portfolio to include protein post-translational modification analysis and complex protein mixture analysis. These efforts collectively represent a $2.8 million commitment from the NCCC and From Dartmouth Medical School to bring a modern proteomics platform within reach of Cancer Center investigators and the greater Dartmouth research community as a whole. During this one-year transition phase, the PRSR received $12,700 in chargebacks from 9 NCCC research laboratories, or 87% of the total ($14,600) chargebacks for the facility (from a collective 16 Dartmouth laboratories). We estimate that the total operating cost of the PRSR for FY 2008 (year 1 of the CCSG renewal) will be $326,760 and anticipate $40,000 in total chargebacks, requiring $48,349 from CCSG and $238,411 from other sources for NCCC investigators (75% of the shortfall). Owing to the rapid increase in demand for PRSR services over the past year, we anticipate strong growth in the rate of chargebacks for the PRSR such that the large subsidy by NCCC and the institution can be reduced. Currently, support funds for the PRSR in transition are provided by multiple institutional sources.