Neuropsychological Progression of New Onset Epilepsy

这个ARRA应用程序代表RO1-44351的扩展，即第一个前瞻性队列研究 新发癫痫儿童的病因和自然病史特征 认知、脑结构和精神病理学方面的神经发育异常。我们的长期目标是 了解儿童发病后不良生活质量结局的原因和最早危险因素 癫痫。 这项横断面和纵向队列研究相结合的研究包括：a)对认知、大脑 初始队列(75名新发癫痫儿童和62名健康对照)的结构和心理健康状况， B)充实了75名新发癫痫儿童和62名健康对照儿童的队列，以及c) 增加了新的神经成像和认知程序，旨在解决关于 严重认知和神经行为共病的神经生物学以及癫痫对 认知和大脑发育。 这项应用的具体目的是：1)表征长期(6年)认知过程 与神经行为合并症相关的发育、脑成熟和精神病理学 起病的儿童癫痫。2)确定与以下疾病相关的独特的皮质形态异常 新发癫痫患者的神经行为合并症。3)确定基线脑白质异常的特征 新发癫痫中识别异常的物质和临床意义。 2.

This ARRA application represents an extension of RO1-44351, the first prospective cohort investigation of children with new onset epilepsy designed to characterize the etiology and natural history of neurodevelopmental abnormalities in cognition, brain structure, and psychopathology. Our long term goal is to understand the causes and earliest risk factors predictive of adverse quality of life outcomes of childhood onset epilepsy. This combined cross-sectional and longitudinal cohort study involves: a) a 6 year follow up of cognition, brain structure, and mental health of the initial cohort (75 children with new onset epilepsy and 62 healthy controls), b) enrichment of the cohort with 75 children with new onset epilepsy and 62 healthy controls, and c) the addition of new neuroimaging and cognitive procedures designed to address hypotheses regarding the neurobiology of critical cognitive and neurobehavioral comorbidities as well as the impact of epilepsy on cognitive and brain development. The specific aims of this application are: 1) Characterize the long term (6 year) course of cognitive development, brain maturation, and psychopathology associated with neurobehavioral comorbidities in new onset childhood epilepsy. 2) Identify the unique abnormalities in cortical morphology associated with neurobehavioral comorbidities in new onset epilepsy. 3) Characterize abnormalities in baseline cerebral white matter and the clinical significance of identified abnormalities in new onset epilepsy. 2.