Alaska INBRE-2: Environmental Agents and Disease

阿拉斯加INBRE-2的这项提案旨在加强和扩大我们的阿拉斯加生物医学研究和培训网络，并确保其自我维持。INBRE-2研究建立在INBRE-1取得的进展的基础上，以填补阿拉斯加在基础细胞生物学以及环境中的化学和微生物病原体方面的专业知识，包括新出现的传染性人畜共患病，如禽流感和兔热病。这些微生物学和毒理学主题与阿拉斯加强大的生态计划相结合。BRIN和INBRE聘请了7名教师，他们在研究和教学生涯中起步良好，并且已经成功地竞争联邦研究赠款。生物信息学/计算核心和仪器支持将继续成为阿拉斯加大学（UA）所有校区生命科学项目的资产。主要的INBRE-2投资集中在7个额外的教师，学生，教师设置，合作研究伙伴关系（包括与国家公共卫生实验室的联合任命），研究的行政支持和教育推广。我们的INBRE教师社区包括那些由INBRE-1，其他附属UA教师谁正在成为生物医学研究的合作者，以及新员工，以填补在微生物学，毒理学，细胞生物学和临床转化研究应用的差距聘请。 其中一位新科学家是阿拉斯加大学系统生物医学研究的执行主任。该网络的举措与普遍获得服务的举措平行，并与普遍获得服务的主要优先事项和不断演变的治理密切相关。阿拉斯加INBRE网络有两个主要节点，分别位于UAA（安克雷奇）和UAF（费尔班克斯）。INBRE与以下机构建立了伙伴关系：州公共卫生部，其他较小的大学单位，K-12教育，健康提供社区，以及西北地区的合作者。它支持研究生奖学金和本科生研究奖，并使学生了解校园研究机会的过程正式化。它继续赞助博士后研究员，并鼓励他们融入联合大学的学术文化。它资助并促进了一系列针对大学预科学生的项目，特别是那些阿拉斯加土著人占多数的农村学生。我们协助，培训和辅导学生在高中做研究，在暑期课程中学习现代生物学，过渡到大学，在大学做研究和申请研究生培训。吸引阿拉斯加农村学生进入大学的教育管道可以成为一个双向管道，鼓励这些社区更好地教我们他们所知道的和他们需要的。 公共卫生相关性（由申请人提供）：阿拉斯加INBRE解决全球卫生优先事项：新出现的传染性病原体，污染物对食品质量和安全的影响，招募土著人民进入卫生事业，以及将生物医学科学与生态学观点相结合。阿拉斯加是大气污染物的倾倒场，也是东半球和西半球之间新出现的人畜共患病媒介物交换的交叉点。通过建设生物医学能力，我们使阿拉斯加有能力应对禽流感等新威胁。

DESCRIPTION (provided by applicant): This proposal for Alaska INBRE-2 aims to strengthen and expand our Alaska network for biomedical research and training and to ensure that it is self-sustaining. INBRE-2 research builds on the advances made in INBRE-1 to fill out Alaska expertise in basic cell biology and in chemical and microbial disease agents from the environment, including emerging infectious zoonotic diseases like avian influenza and tularemia. These microbiology and toxicology themes interface with the strong ecology programs in Alaska. BRIN and INBRE hired 7 faculty who are well-started on their research and teaching careers and are already competing successfully for federal research grants. The bioinformatics/computational core and instrumentation support will continue to be assets for programs across the life sciences on all campuses of the University of Alaska (UA). Major INBRE-2 investments focus on 7 additional faculty, students, faculty setups, collaborative research partnerships (including joint appointments with state public health labs), administrative support for research, and educational outreach. Our INBRE faculty community includes those hired by INBRE-1, other affiliate UA faculty who are becoming collaborators in biomedical research, and new hires to fill in gaps in microbiology, toxicology, cell biology, and clinical-translational applications of research. One of the new scientists is an executive director for biomedical research for the Alaska university system. INBRE initiatives parallel UA's own and are tightly linked to mainline UA priorities and evolving governance. The Alaska INBRE network has two major nodes, at UAA (Anchorage) and UAF (Fairbanks). INBRE has partnerships with: the State Department of Public Health, other smaller college units, K-12 education, the health delivery community, and collaborators in the Northwest region. It supports graduate fellowships and undergraduate research awards and formalizes the process of making students aware of on-campus research opportunities. It continues to sponsor postdoctoral fellows and to encourage their integration into the UA's academic culture. It funds and facilitates a suite of programs for pre-college students, particularly those in rural villages where Alaska Natives are in majority. We assist, train, and counsel students to do research in high school, to learn modem biology in summer courses, to transition to college, to do research in college and to apply for post-graduate training. The educational pipeline that draws students from rural Alaska toward the university can become a two-way conduit that encourages these communities to better teach us what they know and what they need. PUBLIC HEALTH RELEVANCE (provided by applicant): Alaska INBRE addresses global health priorities: emerging infectious agents, contaminant impacts on food quality and safety, recruitment of indigenous peoples into health careers, and integration of bench biomedical science with ecological perspectives. Alaska is a dump-site for atmospheric contaminants and the cross-over point for exchanges of emerging zoonotic agents between eastern and western hemispheres. By building biomedical capacity, we make Alaska competent to respond to new threats like avian influenza.