INBRE-2 CHEMICAL ECOLOGY OF THE PISCIVORE GUT

INBRE-2 食鱼肠道的化学生态学

• 批准号: 8359586
• 负责人: Todd M. O'Hara
• 金额: $ 5.22万
• 依托单位: UNIVERSITY OF ALASKA FAIRBANKS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359586
• 关键词: Alaska; Area; Biological Availability; Blood; Chemicals; Colorado; Disease; Ecology; Funding; Gastrointestinal Contents; Gastrointestinal tract structure; Grant; Intestines; Laboratories; Liver; Location; Mercury; Metabolic Biotransformation; Molecular; National Center for Research Resources; Parasites; Principal Investigator; Research; Research Infrastructure; Resources; Source; Tissues; Toxic effect; Toxicology; United States National Institutes of Health; Universities; Weight; cost; environmental agent; feeding; gastrointestinal; stable isotope

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Wildlife Toxicology Laboratory (PI Todd O'Hara) and Dr. Lora Ballweber (collaborator) from Colorado State University (molecular parasitolgy) propose a research topic in the area of gastrointestinal "ecology" of Hg distribution, dynamics and biotransformation in the intestine of select carnivores (piscivores) to determine relevance in bioavailability and potential toxicity. We will initially focus on macroparasites for which we will determine the "chemical feeding ecology" using C and N stable isotopes and the concentrations and proportions of total Hg and methyl mercury (MeHg). We then assess the compartments with the gut to determine if Hg is partitioning to specific compartments (including macroparasites). We will determine the "trophic level" of the parasite and determine if this correlates with THg and/or MeHg and compare the Hg concentrations within the parasite to the surrounding gut contents and that of other tissues (gut wall, liver, blood, etc.). Our first question asks; Does the "trophic level", morphometrics, location in the gastrointestinal tract, Se concentration, and genera/species of the macroparasite associate with whole parasite body Hg concentration as total Hg and MeHg as wet weight and dry weight? The second question is: Does the Hg concentration (total Hg and MeHg as wet weight and dry weight) of the gastrointestinal contents vary by location and/or fraction in the gastrointestinal tract and vary from that of the macroparasites (e.g., do the macroparasites biomagnify the Hg and/or biotransform it)?

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 科罗拉多州立大学（分子寄生虫）的野生动植物毒理学实验室（Pi Todd O'Hara）和Lora Ballweber（合作者）（合作者）提出了一个研究主题，该研究主题是胃肠道“生态学”的“生态学”领域的研究主题。我们最初将专注于大型矿物，我们将使用C和N稳定同位素以及总HG和甲基汞（MEHG）确定“化学喂养生态”。然后，我们与肠道评估隔室，以确定HG是否在分配到特定隔室（包括大型植物）。我们将确定寄生虫的“营养水平”，并确定这是否与THG和/或MEHG相关，并将寄生虫内的HG浓度与周围的肠道含量和其他组织（肠壁，肝脏，血液等）进行比较。我们的第一个问题问； “营养水平”，形态计量学，胃肠道中的位置，大型岩石岩的浓度和属/物种与整个寄生虫体Hg浓度相关联，作为湿重和干重的总HG和MEHG？第二个问题是：胃肠道含量的Hg浓度（总HG和MEHG作为湿重和干重）是否因位置和/或胃肠道中的位置和/或分数而异，并且与大型乳液的浓度不同（例如，大型果皮生物磁场是否会使HG和/或生物培养物对HG进行生物磁化）吗？