Novel Algorithms and Device for Quantification of Wake-Sleep States

描述(由申请人提供)：该项目的总体目标是开发一种手段(硬件、算法、电极附件)，以从根本上改进对睡眠结构和质量以及白天嗜睡的长期监测方法。将在该项目中开发的设备(称为神经记录仪)将用于评估睡眠障碍和日间嗜睡，特别强调对原发性失眠的诊断和治疗。慢性失眠影响10%至15%的成年人(非住院老年人的患病率为57%)，另外25%至35%的成年人患有暂时性或偶发性失眠。失眠与严重的个人和社会经济负担有关，而且在很大程度上没有得到充分认识，治疗不当或不适当(包括过度用药)。该项目的具体目标是开发Neurolog，作为一种可穿戴的(患者可以轻松部署)、全自动和(高度)定量的脑电波和清醒睡眠阶段分析仪，用于夜间睡眠和白天嗜睡的延长，并用于患者的正常家庭环境。Neurolog将利用在第一阶段开发的用于量化觉醒-睡眠转换的新算法。该设备将在正常受试者以及失眠患者中进行广泛的临床评估和验证。这一创新设备将有可能显著改善对有失眠症状的睡眠障碍的管理，以及经常与失眠有关的一些精神障碍，特别是抑郁症。公共卫生相关性：将在该项目中开发的设备(Neurolog“)将用于评估睡眠障碍和日间嗜睡，特别强调对原发性失眠的诊断和管理。Neurolog将被开发为一种可穿戴的(患者可以轻松部署)、全自动和(高度)定量的脑电波和清醒睡眠阶段的分析器，用于夜间睡眠和白天困倦的延长，并用于患者的正常家庭环境。这一创新设备将有可能显著改善对有失眠症状的睡眠障碍的管理，以及经常与失眠有关的一些精神障碍，特别是抑郁症。

DESCRIPTION (provided by applicant): The overall goal of this project is to develop the means (hardware, algorithm, electrode attachments) for a fundamentally improved method for long-term monitoring of sleep architecture and quality, as well as daytime sleepiness. The device that will be developed in this project, (referred to as NeuroLOG"), will be utilized for assessment of sleep disorders and daytime sleepiness with a particular emphasis on the diagnosis and management of primary insomnia. Chronic insomnia affects 10-15% of adults (with a prevalence of 57% in non-institutionalized elderly persons), and an additional 25 to 35 percent of adults have transient or occasional insomnia. Insomnia is associated with significant personal and socioeconomic burden, and is largely under- recognized and inadequately or inappropriately treated (including overmedication). The specific aim of the project is to develop NeuroLOG as a wearable (and easily deployable by the patient), fully-automated, and (highly) quantitative analyzer of brain waves and wake-sleep stages for extended night- time sleep, and daytime sleepiness, and for use in the patients' normal home environment. NeuroLOG will take advantage of the novel algorithms for quantifying wake-sleep transitions that was developed in Phase I. The device will undergo extensive clinical evaluation and validation with normal subjects as well as patients with insomnia. This innovative device will have the potential to significantly improve the management of sleep disorders with insomnia symptoms, as well as a number of psychiatric disorders that are often associated with insomnia, particularly depression. PUBLIC HEALTH RELEVANCE: The device that will be developed in this project (NeuroLOG") will be utilized for assessment of sleep disorders and daytime sleepiness with a particular emphasis on the diagnosis and management of primary insomnia. NeuroLOG will be developed as a wearable (and easily deployable by the patient), fully-automated, and (highly) quantitative analyzer of brain waves and wake-sleep stages for extended night-time sleep, and daytime sleepiness, and for use in the patients' normal home environment. This innovative device will have the potential to significantly improve the management of sleep disorders with insomnia symptoms, as well as a number of psychiatric disorders that are often associated with insomnia, particularly depression.