EMOTIONS

源自基础情绪研究的基于实验室的方法可以提供细粒度的、活体的 额颞叶变性(FTLD)和阿尔茨海默病患者的情绪功能评估 (AD)两种最常见的痴呆症。在下一个项目期，我们将继续和扩大 这种翻译研究策略，使用这些方法来检查多个情绪过程(反应性， 规则、知识、社会情绪行为)、多种情绪反应系统(外周生理， 表达行为、主观体验、眼球运动、语言)、多个情感家族(积极的、 消极的、自觉的情绪)，以及多种情绪背景(个人内和人际间) 患者、AD患者和年龄匹配的正常对照组。与这次重建的其他项目一样，我们将 进一步强调：(A)区分额颞叶痴呆(FTD)的FTLD亚型， 进行性非流利性失语(PNFA)和语义性痴呆(SD)；(B)绘制情绪功能图 与指定大脑区域的容量减少和低灌流有关，以及(C)探索 肌萎缩侧索硬化症(ALS)患者。这项研究涉及六个具体目标：(1)使用 源自基础情绪研究的评估情绪功能的方法(反应性、调节、 对FTLD和AD的了解；(2)通过研究二元数来评估FTLD和AD患者的社会行为 与照顾者的互动；(3)评估脑容量损失的特定区域与 情绪功能和社会行为的低灌注率和伴随的缺陷及保存；(4) 描述FTLD亚型(FTD、PNFA、SD)之间以及这些亚型之间的情绪功能差异 亚型和肌萎缩侧索硬化症；(5)评估低水平情绪过程的完整性(惊吓眨眼调制 通过情绪、由情绪刺激捕捉的眼动和搜索模式，前注意加工 情绪信息)；以及(6)确定神经心理学和AD之间的关系 认知功能的床边测量和基于实验室的情绪功能评估。这 研究对公众健康有显著的好处。我们相信这些发现将被证明是非常有用的 提高临床诊断的准确性，监测疾病的进展，了解 症状学的基础，评估当前和未来治疗的有效性，并在帮助 提高患者及其家属的生活质量。

Laboratory-based methods derived from basic emotion research can provide a fine-grained, in vivo assessment of emotional functioning in frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD) two of the most common dementing disorders. In the next project period, we will continue and expand this translational research strategy, using these methods to examine multiple emotion processes (reactivity, regulation, knowledge, socioemotional behavior), multiple emotion response systems (peripheral physiology, expressive behavior, subjective experience, eye movements, language), multiple emotion families (positive, negative, self-conscious emotions), and multiple emotion contexts (intrapersonal and interpersonal) in FTLD patients, AD patients, and age-matched normal controls. As with the other projects in this renewal, we will increase our emphasis on: (a) distinguishing between FTLD subtypes of frontotemporal dementia (FTD), progressive non-fluent aphasia (PNFA), and semantic dementia (SD); (b) mapping emotional functioning on to volume loss and hypoperfusion in designated brain regions, and (c) exploring emotional functioning in patients with amyotrophic lateral sclerosis (ALS). The research addresses six specific aims: (1) to use methods derived from basic emotion research to evaluate emotional functioning (reactivity, regulation, knowledge) in FTLD and AD; (2) to evaluate social behavior in FTLD and AD patients by studying dyadic interaction with caregivers; (3) to evaluate relationships between specific regions of brain volume loss and hypoperfusion and attendant deficits in and preservation of emotional functioning and social behavior; (4) to delineate differences in emotional functioning among FTLD subtypes (FTD, PNFA, SD) and between these subtypes and ALS; (5) to evaluate the integrity of low-level emotional processes (startle eye-blink modulation by emotion, eye-movement capture by and search patterns for emotional stimuli, preattentive processing of emotional information) in FTLD and AD; and (6) to determine the relations between neuropsychological and bedside measures of cognitive functioning and laboratory-based assessment of emotional functioning. This research has significant public health benefits. We believe the findings will prove to be extremely useful in improving the accuracy of clinical diagnosis, monitoring the course of disease progression, understanding the basis of symptomatology, evaluating the effectiveness of present and future treatments, and in helping improve quality of life for patients and their families.