Northern California Cooperative Family Registry for Breast Cancer

描述（由申请人提供）：自1995年成立以来，乳腺癌家庭登记处（Breast CFR），一个由六个合作网站组成的国际联盟，已经招募了13，000多个乳腺癌风险范围广泛的家庭。北方加州乳腺癌家庭登记处（NC-FRBC）为该资源做出了重大贡献，并收集了有关家族史、流行病学风险因素和饮食摄入的高质量数据，以及2,600多个家庭的生物标本，其中包括1,900个少数民族家庭，占所有登记的少数民族家庭的70%。NC-FRBC为Breast CFR带来了许多优势，例如经验丰富的领导和合作伙伴，基于人口的抽样，有针对性的少数民族招募，新的分析方法和成功的数据利用。是项为期五年的延续拨款的目的是：1）建立及维持一个以假设为主导的研究基础设施，以加快及推行有关乳癌遗传流行病学的跨学科及跨院校合作研究; 2）重组现有基础设施，使之成为九个核心平台，并维持及进一步加强现有资源; 3）再招募830个基于人口的少数民族家庭（470个西班牙裔，360个非洲裔美国人）。与每个平台相关的核心活动包括：a）对1995-2005年入组的先证者和亲属进行系统随访，并继续对1995-2009年入组的所有先证者进行年度随访; B）在特别关注的家族中扩大数据和生物标本收集（即，多例早发性和BRCA 1和SRC/42突变携带者）; c）扩大先证者和受影响亲属的临床和预后数据收集; d）扩大肿瘤块收集，以构建组织微阵列; e）加强现有生物标本资源，建立重复储存库; f）扩大BRCA 1和BRCA 2突变检测; g）保持和加强当地信息学能力; h）提供资源以促进行为和心理社会研究; i）协调内部登记功能以及与Breast CFR和外部研究者的合作。这种增强和扩大的资源将促进广泛的研究，从识别与乳腺癌风险相关的遗传因素及其与环境和其他遗传修饰剂的相互作用，到解决乳腺癌临床，行为和预防方面的转化研究。

DESCRIPTION (provided by applicant): Since the establishment in 1995, the Breast Cancer Family Registry (Breast CFR), an international consortium of six collaborating sites, has enrolled over 13,000 families across a wide range of breast cancer risk. The Northern California Family Registry for Breast Cancer (NC-FRBC) has contributed significantly to the resource and collected high-quality data on family history, epidemiologic risk factors and dietary intake, as well as biospecimens for over 2,600 families, including 1,900 minority families, which account for 70 percent of all enrolled minority families. The NC-FRBC brings many strengths to the Breast CFR, such as experienced leadership and collaborative partners, population-based sampling, targeted recruitment of minorities, new analytic methods, and successful data utilization. The objectives of this 5-year renewal grant are to: 1) establish and maintain a hypothesis-driven research infrastructure to expedite and implement collaborative, multi-disciplinary and multi-institutional research in genetic epidemiology of breast cancer; 2) re-structure the current infrastructure into nine Core Platforms and maintain and further enhance the existing resources; and 3) recruit an additional 830 population-based minority families (470 Hispanics, 360 African Americans). Core activities associated with each Platform include: a) conduct a systematic follow-up of probands and relatives enrolled from 1995-2005, and continue annual follow-up of all probands enrolled from 1995-2009; b) expand data and biospecimen collection in families of special interest (i.e., multiple case early-onset and BRCA1 and SRC/42 mutation carriers); c) expand clinical and prognostic data collection on probands and affected relatives; d) expand tumor block collection to construct tissue microarrays, e) enhance existing biospecimen resources and establish a duplicate repository; f) expand BRCA1 and BRCA2 mutation testing; g) maintain and enhance local informatics capabilities; h) contribute to resources to facilitate behavioral and psychosocial research; and i) coordinate internal registry functions and collaborations with Breast CFR and external investigators. This enhanced and expanded resource will facilitate a broad spectrum of research, ranging from identification of genetic factors related to breast cancer risk and their interactions with environmental and other genetic modifiers, to translational studies addressing clinical, behavioral and preventive aspects of breast cancer.