Evolutionary Dynamics of Brain, Lung, and Hematopoietic Tumors

描述(由申请者提供)：PS-OC已经组织了一个领导结构来提供专业知识并全面支持所有倡议。领导层由首席调查员Franziska Michor博士和高级联合调查员Eric Holland医学博士组成。支持人员包括行政长官/教育主任，沙漠马-格兰特，研究/项目经理，拉克尔·桑切斯，工商管理硕士，以及生物统计学家，米塞特·贡南博士。PS-OC领导和支助人员，也称为行政部门，将共同努力，支持和完成拟议的研究项目、核心、教育和培训单位、外联和传播单位以及试点和跨网络项目。PS-OC指导委员会(PSC)将每年召开一次会议，每个PS-OC将由两名调查员组成。首席调查员Franziska Michor博士和高级联合调查员Holland博士将在PSC代表我们的PS-OC。中心咨询委员会(CAC)将汇集在物理科学和基础科学方面都有专长的研究人员，组成一个由有投票权和无投票权的成员组成的小组。具体地说，CAC将由以下投票成员组成：两名物理成员Franziska Michor(PD/首席研究员)，PhD和Chris Sander，PhD；两名生物/临床成员，William Pao，医学博士和Eric Holland，医学博士/博士；以及一名NCI指定的投票成员。无投票权的成员将包括至少两名具有广泛专业知识的外部顾问，一名外部顾问将在信号转导、癌症生物学、项目管理方面拥有广泛的熟练程度，并专注于与PS-OC项目无关的肿瘤类型。至少另一名外部顾问将拥有以下一项或多项的高级知识：进化论、非进化性癌症系统、发育生物学、脑癌、肺癌、白血病、应用数学或工程/微制造。

DESCRIPTION (provided by applicant): The PS-OC has organized a leadership structure to provide expertise and fully support all initiatives. The leadership consists of the Principal Investigator, Franziska Michor, PhD, and the Senior Co-investigator, Eric Holland, MD, PhD. Support personnel consists of the Administrator/Education Director, Desert Horse-Grant, Research/Project Manager, Raquel Sanchez, MBA, and Biostatistician, Mithat Gonen, PhD. The PS-OC leadership and support personnel, also known as the Administration, will work collectively to support and accomplish the proposed research projects, core, educational and training unit, outreach and dissemination unit, and pilot and trans-network projects. The PS-OC Steering Committee (PSC) will meet annually and will consist of two investigators from each PS-OC. The Principal Investigator, Dr. Franziska Michor, and the Senior Co-investigator, Dr. Holland, will represent our PS-OC at the PSC. The Center Advisory Committee (CAC) will bring together investigators with expertise in both the physical sciences and the basic sciences to form a group of voting and non-voting members. Specifically, the CAC will be made up of the following voting members: two physical sciences members, Franziska Michor (PD/Principal Investigator), PhD, and Chris Sander, PhD; two biological/clinical members, William Pao, MD/PhD, and Eric Holland, MD/PhD; and an NCI appointed voting member. Non-voting members will include at least two external advisors with a wide spectrum of expertise, One external advisor will have a broad proficiency in signal transduction, cancer biology, program management and a focus on a tumor type unaffiliated with the projects of the PS-OC. At least one other external advisor will have advanced knowledge of one or more of the following: evolutionary theory, non-evolutionary cancer systems, developmental biology, brain cancer, lung cancer, leukemia, applied mathematics or engineering/micro fabrication.