QUANTITATIVE AND QUALITITATIVE FLUORESCENCE MODULATED IMAGING AND TOMOGRAPHY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是通过对荧光团模体的定量和定性测量来演示荧光调制成像(FMI)。我们将研究模体中不同空间和深度分布的荧光微扰。定性地，荧光团的空间局部化能力。在定量方面，将研究测量荧光团浓度以及与浓度和pH无关的荧光团指标(如量子产率)的能力。最后，将并行开发层析重建算法。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to demonstrate Fluorescent modulated imaging (fMI) via the quantitative and qualitative measurement of fluorophore phantoms. Fluorescent perturbations with various spatial and depth profiles in phantoms will be investigated. Qualititatively, the ability for spatial localization of the fluorophore. Quantitatively, the ability to measure fluorophore concentration as well as concentration and pH independent fluorophore metrics such as quantum yield will be investigated. Finally, tomographic reconstruction algorithms will be developed in parallel.