OPTICAL BIOPSY OF HUMAN SKIN IN CONJUCTION WITH LASER TREATMENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是量化治疗前后皮肤和邻近正常皮肤(活体)的光学性质和发色团浓度。此外，在某些情况下，我们将重复进行测量，以记录治疗后皮肤和邻近正常皮肤在几周内的变化。最终，我们感兴趣的是详细了解皮肤对治疗的反应，以优化治疗。此外，我们将比较SS-FDPM和调制成像的结果，以便客观地评估每种技术的优点和缺点。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this study is to quantify optical properties and chromophore concentrations for pre and post treatment skin and adjacent normal skin (in-vivo). Furthermore, in select cases, we will repeatedly perform measurements to record changes in post treatment skin and adjacent normal skin over a period of several weeks. Ultimately we are interested in developing a detailed understanding of the response of skin to therapy with the objective of optimizing therapy. Furthermore we will compare results obtained with SS-FDPM to those arrived at using Modulated Imaging in order to objectively assess the strengths and weaknesses of each technique.