Abnormality of Emotional Circuitry as a Biomarker in PTSD

描述（由申请人提供）：本申请涉及广泛的挑战领域（03）生物标志物的发现和验证，以及特定的挑战主题，03- mh -101精神障碍中的生物标志物。创伤后应激障碍治疗结果的可变性，复发的高风险以及只有一小部分创伤受害者发展为创伤后应激障碍的事实是该疾病尚未解决的方面。然而，目前还没有任何测试或标记可以帮助指导治疗决策，比如应该对特定患者实施哪种治疗，应该治疗多长时间，或者是否可以在发病前及早发现高风险的创伤受害者。因此，我们开发了一个创伤后应激障碍的情绪回路异常模型。在当前应用的资助下，我们建议验证这些异常作为创伤后应激障碍的生物标志物，可以进一步发展以指导治疗决策。创伤后应激障碍（PTSD）是一种常见的、严重的精神问题，发生在一些人的创伤事件之后。治疗结果多变且不完整。复发是常见的。异常情绪回路的脑生物标志物可以提供治疗不足和复发高风险的证据。生物标志物可以识别出更适合特定治疗的亚组患者。

DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (03) Biomarker Discovery and Validation, and specific Challenge Topic, 03-MH-101 Biomarkers in mental disorders. The variability of treatment outcome in PTSD, the high risk of relapse and the fact that only a subset of trauma victims develop PTSD are unsolved aspects of the illness. Yet at the current time there are no tests or markers that can help guide treatment decisions about which treatment should be administered to a particular patient, how long the person should be treated or whether trauma victims at high risk can be identified early, prior to the onset of illness. We have therefore developed a model of emotional circuitry abnormalities in PTSD. With funding of the current application we propose to validate these abnormalities as biomarkers in PTSD that can be further developed to guide treatment decisions. Post Traumatic Stress Disorder (PTSD) is a common, severe psychiatric problem that occurs in some people following a traumatic event. Treatment outcomes are variable and incomplete. Relapse is common. Brain biomarkers of abnormal emotional circuitry could provide evidence of insufficient treatment and high risk for relapse. Biomarkers could identify subgroups of patients who are better suited to a particular treatment.