Women's Interagency HIV Study (WIHS) IV, Chicago Consortium

WIHS是一项多中心前瞻性流行病学队列研究，研究对象为1994年和2002年入组的女性， 感染艾滋病毒或感染艾滋病毒的风险增加。本研究旨在 继续随访WIHS队列，从而支持HIV自然史和治疗史的研究 感染的代表性，主要是少数民族，成年妇女在美国，以及支持研究 与长期艾滋病毒感染和治疗有关的新问题。WIHS-IV科学倡议将 包括正在进行的核心研究项目和启动关于对 抗逆转录病毒治疗和艾滋病毒感染的长期后果以及艾滋病毒治疗 心血管疾病、肝病、脑功能、神经认知障碍、癌症和其他 发病率，以及发展为艾滋病和死亡。此外，在WIHS-IV资助周期内， 合作将继续扩大独立的，由赞助商驱动的研究赠款。 作为一项正在进行的队列研究，芝加哥研究中心将继续支持整体WIHS科学研究 研究议程，继续从参与者那里收集高质量的数据和标本， 队列保留。芝加哥的研究中心还将在包括艾滋病毒学在内的关键领域发挥领导作用 和宿主免疫学，HIV感染的长期发病机制和治疗毒性，以及病毒感染的影响。 阻力课程将包括丙型肝炎（HCV）和B病毒等合并感染的影响 (HBV)人乳头瘤病毒（HPV）;治疗使用和妇女，行为和 影响HIV疾病的社会心理因素，代谢异常的影响，激素因素的影响 艾滋病毒疾病的影响;衰老和更年期对艾滋病毒疾病的影响，环境和 宿主遗传因素对艾滋病毒疾病的影响;以及评估大脑结构，神经认知功能， WIHS参与者的身体损伤。

The WIHS is a multi-site prospective epidemiology cohort study of women enrolled in 1994and 2002 who either are infected with HIV or are at increased risk for acquiring HIV infection. The purpose of the study is to continue follow-up of the WIHS cohort, thereby supporting studies of the natural and treated history of HIV infection in representative, primarily minority, adult women in the United States, as well as supporting studies of emerging questions related to long-term HIV infection and treatment. WIHS-IV scientific initiatives will include ongoing core research projects and the initiation of new projects on the predictors of response to antiretroviral therapy and long term consequences of HIV infection and HIV therapy in terms of cardiovascular disease, liver disease, hormonalfunction, neurocognitive impairment, cancer and other morbidities, as well as progression to AIDS and death. Additionally during the WIHS-IV grant cycle scientific collaborations will continue to expand independent, investigator-driven research grants. As an ongoing cohort study that, The Chicago site will continue to support the overall WIHS scientific research agenda by continuing to collect quality data and specimens from participants and maintain superb cohort retention. The Chicago site will also provide leadership for key areas of interest including HIV virology and host immunology, long term pathogenesis of HIV infection and treatment toxicities, and impact of viral resistance. Topics of study will include the effect of co-infections such as hepatitis C (HCV) and B virus (HBV), human papillomavirus (HPV); therapy use and treatment effects in women, behavioral and psychosocial factors influencing HIV disease, effects of metabolic abnormalities, impact of hormonal factors on HIV disease; the effects of aging and menopause on HIV disease, the interaction of environmental and host genetic factors on HIV disease; and the assessment of brain structure, neurocognitive functioning, and physical impairment among WIHS participants.