TRAINING IN SIGNALING AND CELLULAR REGULATION

描述(由申请人提供)：这项培训资助提案的目标是为有天赋的博士前受训人员在信号和细胞调节领域从事富有成效的研究事业做准备。培训人员由一群杰出的、国际公认的部门调查人员组成。化学和生物化学；分子、细胞、发育生物学；应用数学；以及化学和生物工程，通过发现和表征信号通路中的关键成分，通过蛋白质构象变化和翻译后修饰传递生物信息，对复杂的生物通路进行数学建模，以及制定人类疾病的新治疗策略，研究基本的细胞调控机制。该计划为学生提供实验设计、科学技术和数据评估方面的严格培训，接触广泛的科学学科，课堂教学培训，科学陈述机会，以及职业行为标准培训。在第一年，学生们在自己的家庭部门完成课程作业和教学任务，并进行实验室轮换。在第一年结束时，学生们选择一位论文导师，并选择参加这个培训计划。在第二年，学生开始研究和选修为这个项目量身定做的课程。通过笔试和口试，包括对论文研究提案的辩护，才能获得博士候选人资格。在第三年及以后，学生通过论文项目获得高水平的研究培训，并每年监测进展，直到毕业。学生们通过参加项目超级小组、期刊俱乐部和研讨会，以及在广大观众面前展示他们的作品，来增加他们的广度和知识。学生通过为博士论文辩护来完成课程，并获得生物化学或MCDB博士学位。大多数学生在入学后5-6年内完成学业，并继续接受博士后培训，并在学术界、研究机构或制药/生物技术公司从事职业。

DESCRIPTION (provided by applicant): The goal of this training grant proposal is to prepare gifted predoctoral trainees for productive research careers in the field of signaling and cellular regulation. The training faculty consists of an outstanding, internationally recognized group of investigators in the Depts. of Chemistry and Biochemistry; Molecular, Cellular, Developmental Biology; Applied Mathematics; and Chemical and Biological Engineering, who study basic cell regulatory mechanisms through discovery and characterization of key components in signaling pathways, transfer of biological information through protein conformational changes and posttranslational modifications, mathematical modeling of complex biological pathways, and formulation of new therapeutic strategies for human diseases. The program provides students with rigorous training in experimental design, scientific technique, and data evaluation, exposure to a wide range of scientific disciplines, training in classroom teaching, opportunities for scientific presentation, and training in standards for professional conduct. In Year 1, students take coursework and teaching duties in their home departments, and carry out laboratory rotations. At the end of Year 1, students choose a thesis advisor and elect to join this training program. In Year 2, students begin research and take elective coursework tailored to this program. Written and oral qualifying exams including the defense of a dissertation research proposal are required to advance to Ph.D. candidacy. In Years 3 and beyond, students obtain high caliber research training through the thesis project, with progress monitored yearly until graduation. Students add to their breadth and knowledge by participating in program supergroups, journal clubs, and seminars, and by presenting their work before large audiences. Students complete the program by defending a doctoral dissertation and receive a Ph.D. degree in Biochemistry or MCDB. Most students finish within 5-6 years of matriculation, and go on to postdoctoral training and careers in academia, research institutes, or pharmaceutical/biotechnology companies.