Motion Artifact Reduced SDOCT of the Anterior Segment

描述（由申请人提供）：在基于角膜的手术干预中，准确的角膜定量成像对于预测结果至关重要。虽然长期以来，基于反射的角膜地形图评估角膜曲率和屈光能力的标准是不够的，因为角膜形状的手术操作是常规的，破坏了反射地形图的基础。激光屈光手术是一种特殊的角膜干预，它揭示了目前在测量角膜方面的不足。在美国，有超过700万人接受了某种形式的激光屈光手术，以减少他们对矫正眼镜的依赖。通过激光屈光手术进行的角膜重塑为患者带来了良好的视觉效果，但目前的技术无法准确测量角膜重塑的力量。准确测量角膜度数在白内障手术后人工晶状体度数预测等应用中是至关重要的，这类患者随着年龄的增长将不可避免地遇到这种情况。我们建议开发一种基于运动校正的高速光谱域光学相干断层扫描（SDOCT）的设备，该设备可以直接以微米分辨率绘制角膜表面，然后准确地将这些数据转换为角膜测量值，这将极大地帮助依赖于该值的临床应用。主要的创新将是开发新的硬件和软件方法来解释患者的非自愿运动和角膜内OCT光的折射。然后将对接受激光屈光手术的患者进行临床比较，以比较SDOCT测量的角膜功率与现有临床仪器测量的角膜功率。

DESCRIPTION (provided by applicant): Accurate quantitative imaging of the cornea is critical for predictable outcomes in corneal based surgical interventions. While long the standard, reflection based corneal topography to assess corneal curvature and refractive power is insufficient in an era when surgical manipulation of the corneal shape is routine and undermines the basis of reflection topography. Laser refractive surgery is one particular corneal intervention that has revealed current inadequacies in measuring the cornea. Over 7 million people in the United States have had some form of laser refractive surgery to reduce their dependence on corrective eye wear. The corneal reshaping that occurs from laser refractive surgery results in excellent visual results for the patient but renders current technologies incapable of accurately measuring the power of the reshaped cornea. Accurate measurement of corneal power is critical in applications such as the prediction of intraocular lens power needed after cataract surgery, an event which this group of patients will invariably encounter as they age into late adulthood. Our proposed development of a motion corrected high-speed spectral domain optical coherence tomography (SDOCT) based device which can directly map corneal surfaces at micron resolution and then accurately convert this data to keratometric values will greatly aid clinical applications dependent on this value. The primary innovations will be the development of novel hardware and software methods to account for involuntary patient motion and for refraction of OCT light within the cornea. A clinical comparison will then be made in patients undergoing laser refractive surgery to compare the measurements made by SDOCT versus existing clinical instrumentation for the measurement of corneal power. PUBLIC HEALTH RELEVANCE: We propose to develop an improved ocular anterior segment imaging system using spectral domain optical coherence tomography. If successful, this project could support widespread adoption of SDOCT as the preferred, single-platform anterior segment imaging device in eye care delivery.