Optimising myelin repair and restoring neuronal function in the demyelinated brain

多发性硬化症是一种脑部和脊髓的疾病，由脑白质损伤引起。在健康的大脑中，白质中一种名为髓鞘的物质使神经细胞的轴突(电缆)绝缘，从而加快了电传导。在多发性硬化症中，髓鞘被破坏，这会损害传导，并可能导致轴突和神经细胞的永久性丧失。为了防止这种情况，我们将测试神经细胞中增加的电活动是否通过激活髓鞘形成干细胞来帮助恢复髓鞘。

Multiple sclerosis is a disease of the brain and spinal cord caused by damage to white matter. In healthy brains, a substance in white matter called myelin insulates the axons (cables) of nerve cells, which speeds up electrical conduction. In MS, myelin is destroyed which impairs conduction and can lead to permanent loss of axons and nerve cells. To prevent this, we will test whether increasing electrical activity in nerve cells helps restore myelin by activating myelin-forming stem cells.