New Faculty Recruitment in Stem Cell and Regenerative Cardiovascular Biology

描述（由申请人提供）：威斯康星医学院（MCW）的心血管中心（CVC）是一个生物医学核心中心，正在进行与心脏，肺，中风，高血压和肾损伤，糖尿病和肥胖相关的复杂心血管疾病的预防，检测，治疗和治愈相关的研究。最近的战略计划将扩大MCW的心血管研究活动指定为最高优先事项之一。最近扩大的研究空间和资源分配给CVC，以招募新的教师，这表明机构支持这一扩张。我们已经确定了一位令人兴奋的年轻科学家，Aron Geurts博士，他将推进我们在干细胞和再生心血管生物学方面发展卓越创新研究项目的目标。Geurts博士在细胞培养和技术开发方面拥有十年的经验，过去三年一直在Howard Jacob博士的实验室担任人类和分子遗传学中心（HMGC）的博士后。他领导了我们NHLBl-PGA项目的基因诱捕转座子诱变大鼠的开发和应用；用锌指核酸酶建立第一个靶向敲除大鼠；大鼠成纤维细胞重编程为诱导多能干细胞。这项PSO资助将为Geurts博士提供启动资金和保护时间，使他能够作为一名新的终身教职员工发展自己的研究计划，成为一名独立资助的nih支持的研究者。Geurts博士不仅具有特殊的科学技能和实力，而且具有卓越的合作能力，这使他成为CVC与生理学、细胞生物学、神经生物学和解剖学、HMGC以及生物工程和生物技术中心共同开发的干细胞和再生心血管生物学领域的研究资源的有力候选人。校园内丰富的资源将为Geurts博士提供一条独立的道路，同时扩大该机构的多学科研究人员社区，专注于NHLBI的具体利益。

DESCRIPTION (provided by applicant): The Cardiovascular Center (CVC) at the Medical College of Wisconsin (MCW) is a Biomedical Core Center with ongoing research related to the prevention, detection, treatment and cure of the complex set of cardiovascular diseases related to heart, lung, stroke, high blood pressure and renal injury, diabetes, and obesity. The most recent Strategic Plan designated the expansion of the cardiovascular research activities at MCW to be one of the highest priorities. Recent allocation of expanded research space and resources to the CVC to recruit new faculty demonstrates the institutional support of this expansion. We have identified an exciting young scientist, Dr. Aron Geurts, who would advance our goals to develop an innovative research program of excellence in stem cell and regenerative cardiovascular biology. Dr. Geurts with ten years of experience in cell culture and technology development, has been a postdoctoral fellow for the past three years in the Human and Molecular Genetics Center (HMGC) working in the laboratory of Dr. Howard Jacob. He has led the development and application in rats of gene-trap transposon mutagenesis for our NHLBl-PGA program; the creation of the first targeted knockout rats using zinc-finger nucleases; and the reprogramming of rat fibroblasts into induced pluripotent stem cells. This PSO grant would enable the immediate opportunity to provide start-up funds and protected time for Dr. Geurts as a new tenure-track faculty member to develop his own research initiatives to become an independently-funded, NIH-supported investigator. Not only his specific scientific skills and prowess but also his remarkable collaborative abilities make Dr. Geurts a strong candidate for recruitment to enhance research resources in the area of stem cell and regenerative cardiovascular biology developed by the CVC together with the Departments of Physiology, and Cell Biology, Neurobiology and Anatomy, the HMGC, and the Bioengineering and Biotechnology Center. The extensive resources on this campus would provide a pathway of independence for Dr. Geurts while at the same time expanding the institution's community of multidisciplinary researchers focusing on the specific interests of the NHLBI. The CVC has identified an exciting young scientist. Dr. Aron Geurts, who would advance our goals to develop an innovative research program of excellence in stem cell and regenerative cardiovascular biology. The recruitment of Dr. Geurts would enhance research resources in the area of stem cell and regenerative cardiovascular biology for the CVC at MCW.