Biology and Pathobiology of Kr??ppel-Like Factors (KLFs)

描述（由申请人提供）：本申请申请资金部分支持FASEB夏季研究会议（SRC）题为克虏伯样因子（KLFs）的生物学和病理生物学。为期5天的会议是将在美国举行的关于该主题的第一次国际会议。kruppel样因子是一类含锌指的转录因子，代表了一个快速发展的领域。自从这个家族的第一个成员红系Kr| pel- like Factor （EKLF或KLF1）被发现以来，大约16年前，又发现了21个成员。研究表明，KLFs在多种生理过程中发挥重要作用，包括心血管、消化、呼吸、血液和免疫系统，以及癌症、肥胖、糖尿病和炎症等病理状态。最近的研究还表明，KLFs参与体细胞重编程为诱导多能干细胞（iPS）和维持胚胎干细胞的多能性。本次研讨会旨在召集KLF研究领域的一批国际领导人，旨在促进讨论和促进合作。基于KLF生物学的心血管、癌症、糖尿病和炎症性疾病的治疗发展潜力是这次会议可能产生的一个明显的可能性。

DESCRIPTION (provided by applicant): This application requests funding in partial support of a FASEB Summer Research Conference (SRC) entitled Biology and Pathobiology of Kruppel-Like Factors (KLFs). The 5-day conference is the first international meeting on this topic that will be held in the U. S. Kruppel-like factors are a family of zinc finger-containing transcription factors that represents a rapidly advancing field. Since the identification of the first member of this family, Erythroid Kr|ppel-Like Factor (EKLF or KLF1), some 16 years ago, an additional 21 members have been identified. Studies have indicated that KLFs exert important functions in diverse physiological processes involving the cardiovascular, digestive, respiratory, hematological and immune systems and in pathological states such as cancer, obesity, diabetes, and inflammatory conditions, among others. Recent studies have also implicated KLFs in the reprogramming of somatic cells to inducible pluripotent stem (iPS) cells and in maintaining the pluripotency of embryonic stem cells. The proposed symposium is designed to bring together a group of international leaders in the field of KLF research with the goal of stimulating discussion and fostering collaboration. The potential for therapeutic development in cardiovascular, cancer, diabetes, and inflammatory diseases based on KLF biology is a distinct possibility that may result from the meeting. The SPECIFIC OBJECTIVES of the meeting are: a. To provide a scientific program at the forefront of KLF research that is organized around the themes of physiological functions and organ-based pathophysiology of diseases. b. To provide a venue for meaningful interchanges among investigators in the KLF field with which to foster interactions and potential collaborations in both basic and clinical sciences. c. To provide a scientific platform with which to encourage active participation of young investigators and trainees. d. To provide an educational forum to participants. At the end of conference, we will generate a summary of the conference talks and envision that the conference will stimulate robust discussion and exciting new ideas with which to advance the field. We also anticipate to continue the conference platform and establish a biannual conference schedule on similar topics.