Genetics 2010: Model Organisms to Human Biology

描述（由申请人提供）：这是一份申请，旨在支持由美国遗传学会（GSA）主办的题为“遗传学2010：人类生物学的模式生物”的会议，该会议将于2010年6月12日至15日在马萨诸塞州波士顿举行。GSA认为，在这个时代，重要的是召开一次会议，将研究模式生物的研究人员与研究人类生物学和疾病的研究人员聚集在一起。这种结合促进了一个活跃的论坛，供通常不互动的科学家交流成果和想法。对模式生物的研究为我们现代对人类生物学的理解提供了基础，从阐明转录调控机制到为复杂人类特征的全基因组关联研究提供基础的发现。此外，这些研究，沿着最近的基因组测序项目，揭示了生物体在细胞生长的最基本方面高度保守的程度，以及模式生物研究如何与理解人类组织发育，生理学和病理学直接相关。然而，我们仍然需要学习如何最好地将模式生物应用于整个进化谱系，以解决进化适合它们的人类生物学问题。这些挑战需要通常在不同圈子活动的生物学家之间进行积极的讨论。我们认为，这次会议填补了科学界现有资料的一个重大空白。我们还相信，这次会议可以作为一种催化剂，促进NIH鼓励的跨学科举措，许多人认为这是生物学和医学未来进步的源泉。每场会议将包括四名特邀发言人（由联合主席选择），他们主要侧重于模式生物或人类/哺乳动物。此外，将从提交的摘要中选择两个较短的谈话，为年轻的研究人员提供展示其工作的机会，并能够纳入特别感兴趣的最新报道。最后，将有三个主题演讲，由世界著名的科学家（杰里米贝格，卡罗尔格雷德，和加里Ruvkun）。预计会议将吸引约500人参加。它将在波士顿后湾区的波士顿喜来登酒店举行。除当地科学家外，所有与会者都将被安置在现场，并将一起用餐，以促进他们之间的最大互动。残疾人可以进入旅馆，并努力鼓励妇女和代表人数不足的少数民族参与。会议的收费结构旨在鼓励青年科学家的参与。 公共卫生相关性：在理解人类疾病和开发治疗方法方面的进展通常来自于开发更容易研究的动物模型。基因组学告诉我们，许多重要的疾病过程发生在比以前所知的更广泛的动物和模式生物群体中。本次会议将教参与者如何找到和利用理想的模型系统，以增加我们对他们研究的特定疾病或过程的理解。

DESCRIPTION (provided by applicant): This is an application for support of a conference sponsored by the Genetics Society of America (GSA) entitled "Genetics 2010: Model Organisms to Human Biology", to be held in Boston, MA on June 12-15, 2010. The GSA believes that in this age it is important to convene a meeting that brings together investigators who study model organisms with investigators who study human biology and disease. This combination promotes a dynamic forum for the exchange of results and ideas between scientists who do not normally interact. Research on model organisms has provided the foundation for our modern-day understanding of human biology, ranging from elucidating the mechanisms for transcriptional regulation to the discoveries that provided the basis for genome-wide association studies of complex human traits. Moreover, these studies, along with more recent genome sequencing projects, have revealed the remarkable extent to which organisms are highly conserved for most fundamental aspects of cellular growth, and how model organism research is directly relevant to understanding human tissue development, physiology, and pathology. However, we still need to learn how best to apply model organisms across the entire spectrum of phylogeny to those problems of human biology for which evolution has suited them. These challenges require active discussion among biologists who normally move in different circles. We believe this meeting fills a significant gap in what is available to the scientific community. We also believe that this meeting can act as a catalyst for the type of interdisciplinary initiatives that the NIH encourages and that many see as a source of future advances in biology and medicine. Each session will include four invited speakers (chosen by the co-chairs) divided between those with a primarily model organism focus or a human/mammalian focus. In addition, two shorter talks will be chosen from the submitted abstracts, to provide opportunities for younger investigators to present their work and to enable inclusion of late-breaking stories of special interest. Finally, there will be three keynote talks by world renowned scientists (Jeremy Berg, Carol Greider, and Gary Ruvkun). The meeting is expected to attract approximately 500 people. It will be held at the Boston Sheraton in the Back Bay section of Boston. All meeting attendees, except local scientists, will be housed on-site and will take most meals together, to stimulate maximal interaction among them. The hotel is accessible to the handicapped and efforts have been made to encourage participation of women and under-represented minorities. The fee structure for the meeting is designed to encourage participation of young scientists. PUBLIC HEALTH RELEVANCE: Progress in understanding human disease and in developing treatments often comes from developing more easily studied animal models. Genomics has taught us that many important disease processes take place in a much wider group of animals and model organisms than was previously known. This meeting will teach participants how to find and exploit the ideal model system in which to increase our understanding of the particular disease or process that they study.