2010 Thiol-based Redox Regulation & Signaling Gordon Research Conference

描述（由申请人提供）：本提案要求支持将于2010年5月9日至14日在意大利Il Ciocco举行的基于硫的氧化还原调控和信号传导戈登研究会议。氧化还原生物学领域是生物医学科学的关键，因为越来越多的细胞功能和损伤被发现与氧化还原过程有关。氧化还原控制的核心是利用硫醇进行氧化还原化学的系统。含硫醇蛋白是细胞中主要的抗氧化剂，硫醇在各种磷酸酶、激酶和转录因子中的可逆氧化将硫醇为基础的氧化还原化学与磷酸化信号传导、细胞凋亡、基因调控、细胞周期控制等过程和途径联系起来。巯基氧化还原稳态的失调对癌症、心血管疾病和其他复杂疾病的发生和发展具有重要意义，并且是衰老过程的重要组成部分。继2006年和2008年在美国和意大利成功举行两次会议后，本届会议已进入第三轮。本次会议的主席和副主席分别是一名内科科学家和一名基础研究人员，他们是从事该领域各个方面工作的生物学家、化学家和临床医生的代表。这次会议提供了一个自由交流思想和方法的场所（后者往往限制了这一特定领域的进展）。虽然会议的主题领域基础广泛，但其与癌症、心血管疾病和老龄化的相关性在方案上得到了很好的体现。通过将在生物物理方法、生物信息学和动物模型系统方面具有不同专业知识的研究人员与专注于疾病过程的医生聚集在一起，预计会议将进一步刺激合作并催化科学进步，正如之前会议的成功所证明的那样。

DESCRIPTION (provided by applicant): This proposal requests support for a Gordon Research conference on Thiol-based Redox Regulation and Signaling to be held May 9-14, 2010 at Il Ciocco in Italy. The field of redox biology is key to the biomedical sciences as an increasing number of cellular functions and impairments are found linked to redox processes. Central to redox control are systems that utilize thiols to perform redox chemistry. Thiol-containing proteins are major antioxidants in cells and reversible oxidation of thiols in various phosphatases, kinases and transcription factors links thiol-based redox chemistry to phosphorylation-based signaling, apoptosis, gene regulation, cell cycle control and other processes and pathways. Dysregulation of thiol-based redox homeostasis has major implications for the onset and progression of cancer, cardiovascular diseases, and other complex diseases and is a significant component of the process of aging. This conference is in its third cycle after a two very successful meetings in the U.S. and Italy in 2006 and 2008. The chair and vice-chair for this meeting are a physician scientist and a basic researcher, respectively, and are representative of the biologists, chemists and clinicians working on varied aspects of the field. This conference provides a venue for the free exchange of ideas and methodologies (the latter often limits progress in this particular field). While the thematic area of the conference is broad-based, its relevance to cancer, cardiovascular diseases and aging is well represented programmatically. By bringing together investigators with varied expertise in biophysical methods, bioinformatics and animal model systems, with physicians focused on disease processes, the meeting is expected to further stimulate collaborations and catalyze scientific progress as has been exemplified by the successes of the previous meetings.