9th International Conference on Brain Energy Metabolism

描述(申请人提供)：第九届国际脑能量代谢会议将于2010年7月7-10日在匈牙利布达佩斯塞梅尔韦斯大学(http://www.icbem-budapest-2010.org/).)举行，主题为《线粒体-细胞相互作用：从能量学到发病机制》该计划包括两位主旨演讲者和25位特邀演讲者，他们在六个科学会议上发表演讲，主题集中在连续统的特定方面，从线粒体能量学和大脑新陈代谢到能量衰竭与神经疾病发病机制的关系。演讲者包括资深专家和年轻的调查人员，每个会议分配给演讲者和与会者讨论的时间约为30%。学生报告是会议的一个重要方面，它们是帮助新一代科学家进入我们的社区并通过将他们纳入年轻的研究人员演讲者和会议主席而促进他们成熟的有效工具。此外，还有三次海报会议，总计7.5小时，以确保有充足的非正式讨论时间，由与会者进行陈述。这次会议的重点是胞浆和线粒体之间的细胞内通讯，这是一个研究不足的主题，对神经元和星形胶质细胞功能的代谢、生物合成、信号、调节和能量方面以及神经元与星形胶质细胞的相互作用至关重要。尽管细胞质-线粒体相互作用的反应、通量、转运体和调控信号方面对细胞功能和疾病至关重要，但神经科学家们对它们知之甚少。这次会议的主要目标是，历史上一直是，作为前沿讨论的推动力，提出深刻的实验和合作，开辟探索能量代谢的新领域，这些领域是脑部疾病的基础和促成因素，包括中风、退行性疾病和创伤性脑损伤。这一目标将通过一次小型的、集中的会议(大约100-120人参加)来实现，该会议以大脑能量代谢为中心，聚集了世界各地对这一领域有浓厚兴趣的专家、学生和研究员。正式陈述和非正式讨论是这一系列会议的亮点，它促进了长期的科学互动，并在一本科学期刊的同行评议特刊上传播原创研究工作和与会者的评论文章。 与公共健康相关：大脑能量代谢会议是一个为期4天的科学教育活动，与会者将在会上传达与大脑疾病相关的尖端研究成果，这些疾病涉及能量产生和线粒体，线粒体是产生大部分能量的细胞的动力源。中风、糖尿病、帕金森氏症和其他神经退行性疾病等疾病都有严重的能量产生障碍作为基本特征，与他人分享知识可以促进研究，并加快潜在治疗方法从实验室到床边的转移。

DESCRIPTION (provided by applicant): The 9th International Conference on Brain Energy Metabolism entitled "Mitochondrial-Cytosolic Interactions: From Energetics to Pathogenesis" will be held on July 7-10, 2010, at Semmelweis University, Budapest, Hungary (http://www.icbem-budapest-2010.org/). The program includes two keynote speakers and 25 invited speakers in six scientific sessions on topics that focus on specific aspects of the continuum from mitochondrial energetics and brain metabolism to the relationships of energy failure to pathogenesis of neurological diseases. Speakers include established experts and young investigators, with about 30% of the time allocated to each session for speaker-conferee discussions. Student-fellow presentations are an important aspect of the meeting and they are an effective tool to help bring a new generation of scientists into our community and foster their maturation by their inclusion as young investigator speakers and session chairs. In addition, there are three poster sessions for a total of 7.5 hours to ensure plenty of informal discussion time with presentations by conferees. This conference focuses on intracellular communication between the cytosol and mitochondria, which is an under-studied topic that is critical for metabolic, biosynthetic, signaling, regulatory, and energetic aspects of neuronal and astrocytic function, as well as neuron-astrocyte interactions. The reactions, fluxes, transporters, and regulatory signaling aspects of cytosolic-mitochondrial interactions are poorly understood by neuroscientists in spite of their central importance to cellular function and disease. The major goal of this conference is, and has historically been, to serve as a driving force for cutting-edge discussions and formulation of incisive experiments and collaborations that open new areas of exploration of energy metabolism that underlie and contribute to brain diseases, including stroke, degenerative diseases, and traumatic brain injury. This goal will be achieved by a small, focused conference (about 100-120 attendees) that centers around brain energy metabolism and brings together the world's experts, students, and fellows who have a keen interest in this field. Formal presentations and informal discussions are highlights of this conference series that fosters long-term scientific interactions and disseminates original research work and review articles by the conferees in a peer-reviewed special issue of a scientific journal. PUBLIC HEALTH RELEVANCE: The Brain Energy Metabolism conference is a 4-day scientific educational event in which conference attendees will convey cutting-edge results of research related to brain diseases that involve energy production and mitochondria, the powerhouses of cells that generate most of the energy. Diseases such as stroke, diabetes, Parkinson's disease, and other neurodegenerative diseases all have serious disturbances of energy production as an underlying feature, and sharing knowledge with others improves research and speeds the transfer of potential treatments from the laboratory to bedside.