PancreasFest 2010: Defining & Classifying Disease to Enhance Research & Care

描述（由申请人提供）：PancreasFest 2010，定于2010年7月30日至31日在宾夕法尼亚州匹兹堡举行，将汇集来自学术医疗中心的所有职业阶段的医生和科学家，以解决胰腺疾病的病原学，诊断和治疗研究进展和需求。我们将特别汇集该领域的领导者，以更好地定义和分类复发性急性胰腺炎（RAP）和慢性胰腺炎（CP）的病因，诊断，严重程度，进展，并发症和结局。我们还将评估当前和新的成像，监测，治疗和测量对治疗的反应的方式，并回顾有关疾病病因和进展机制的现有研究。作为一个小组，我们将进一步确定每种疾病的最高优先级研究问题，并合作规划多中心试验来解决这些问题。会议还为正在进行的多中心临床试验提供了一个场所，如北美胰腺炎研究2（NAPS 2），急性胰腺炎的喂养和胰腺休息（现在SNAP）和特发性复发性急性胰腺炎（IRAP）。PancreasFest的使命反映了NIDDK的承诺，即了解胰腺疾病的生物学基础，以开发更好的预防、诊断和治疗方法，促进公共卫生。会议计划将有四个主要会议，旨在促进胰腺疾病的合作研究，特别是国家消化疾病委员会在其最近题为消化疾病研究的机遇和挑战的报告中确定的需求。虽然已经取得了令人兴奋的进展，我们的新知识强调了一个事实，即我们的RAP和CP的定义和并发症的分类系统是完全不够的。医生和基础科学家必须聚集在一起讨论最新进展;制定RAP和CP的统一定义，其进展及其并发症;并建议使用或开发更好的措施和生物标志物。一个由10名医生和基础科学家组成的会议委员会，包括非裔美国人和妇女成员，正在制定科学议程和工作文件草案以及用于制定标准定义和分类的参考书目。我们预计，RAP和CP及其并发症的统一定义，以及纤维化，外分泌功能，糖尿病和疼痛的生物标志物的测量原则的建议，几个重要的声明的发展。我们还预计，该计划将为未来的翻译研究奠定基础，这些研究以一种合作的方式构建，从而导致该领域的重大进展。 PancreasFest 2010将为胰腺炎和其他胰腺疾病的患者提供一个论坛，让该领域的领先专家讨论当前研究的结果，并确定诊断，治疗，监测和预防胰腺炎和其他胰腺疾病的最佳方法。没有其他会议关注这些疾病，会议形式鼓励所有与会者参与讨论如何提供最好的临床护理。

DESCRIPTION (provided by applicant): PancreasFest 2010, scheduled for July 30-31, 2010 in Pittsburgh, Pennsylvania, will bring together physicians and scientists at all career stages from academic medical centers to address pathogenic, diagnostic, and therapeutic research progress and needs in pancreatic diseases. We will specifically bring together leaders in the field to better define and classify the etiology, diagnosis, severity, progression, complications, and outcomes of recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP). We will also evaluate current and new modalities for imaging, monitoring, treating, and measuring response to treatment and review available research on mechanisms for the etiology and progression of disease. As a group, we will further identify the highest priority research questions for each disorder and collaborate on the planning of multicenter trials to address these questions. The meeting also provides a venue in which to hold investigator meetings for ongoing multicenter clinical trials, such as the North American Pancreatitis Study 2 (NAPS2), Feeding and Pancreatic Rest in Acute Pancreatitis (now SNAP), and Idiopathic Recurrent Acute Pancreatitis (IRAP). The mission of PancreasFest mirrors that of the NIDDK in its commitment to understand the biological basis of pancreatic disease toward developing improved methods of prevention, diagnosis, and treatment in advancing public health. The conference program will have four major sessions aimed at stimulating collaborative research in pancreatic diseases, particularly those needs identified by the National Commission on Digestive Diseases in their recent report entitled Opportunities and Challenges in Digestive Diseases Research. Although exciting progress has been made, our new knowledge highlights the fact that our definition of RAP and CP and classification system of complications is totally inadequate. Physicians and basic scientists must come together to discuss recent advances; to develop uniform definitions of RAP and CP, their progression, and their complications; and to recommend the use or development of better measures and biomarkers of the components of this disease. The scientific agenda and draft working documents and bibliographies for use in deriving standard definitions and classifications are being developed by a 10-member Conference Committee comprising physicians and basic scientists, including African American and women members. We anticipate the development of several important statements on the uniform definitions of RAP and CP and their complications as well as recommendations on the principles of measuring biomarkers of fibrosis, exocrine function, diabetes, and pain. We also anticipate that this program will lay the groundwork for future translational studies that are cooperatively structured in a way that will lead to major advances in the field. PancreasFest 2010 will benefit patients who have and are at risk for pancreatitis and other pancreatic disorders by providing a forum for leading experts in the field to discuss results of current research and identify the best methods for diagnosing, treating, monitoring, and preventing pancreatitis and other pancreatic disease. No other conference focuses on these disorders, and the meeting format encourages all attendees to participate in the discussion of how to provide the best possible clinical care.