Craniofacial Morphogenesis and Tissue Regeneration Gordon Research Conference

描述(申请人提供)：颅面畸形约占所有先天出生缺陷的三分之一，是婴儿死亡的主要原因，并对国家卫生保健预算产生重大影响。这项提议要求支持作为戈登会议研究系列的一部分，每年举行三次关于颅面发育和组织再生的国际会议。这个应用程序的意义在于，它支持已成为颅面社区卓越会议的会议。这些颅面GRC会议的广泛和长期目标是促进我们对正常颅面发育、疾病和进化的基本机制的理解，在此基础上可以开发新的预防和修复途径来管理和治疗先天性颅面出生缺陷。该应用程序的具体目的是将领先的研究人员聚集在一起，展示关于颅面发育、进化、疾病和再生的分子、细胞和遗传方面的尖端研究。更具体地说，颅面GRC会议将召集大约42名演讲者，代表颅面发育和组织再生的关键领域。该计划将包括8个环节，包括神经脊细胞和安慰剂，骨骼和结缔组织的发育和相互作用，介导细胞通讯的信号通路，人类疾病的动物模型和全基因组关联研究，再生干细胞生物学的进展，以及通过组织工程替代头面部组织。本次会议的大学氛围，以及预定的非正式聚会和海报展示的机会，提供了许多互动讨论的机会，将重点放在颅面生物学领域许多悬而未决的问题和挑战上。这项建议通过促进新颖和创新的研究途径来改善颅面发育中的关键健康问题以及预防先天性颅面畸形综合征，从而实现了国家牙科和颅面研究所战略计划的一系列使命和目标。 与公共卫生相关：头部和面部异常约占所有新生儿出生缺陷的三分之一，是婴儿死亡的主要原因，并对国家卫生保健预算产生重大影响。全面和协调的治疗可以为每个头部和面部出生缺陷提供令人满意的管理。然而，结果很少是完全正确的。因此，需要投入相当大的努力来开发预防的治疗途径，并开发更好的颅面组织修复再生策略。

DESCRIPTION (provided by applicant): Craniofacial abnormalities account for approximately one third of all congenital birth defects, are a major cause of infant mortality and dramatically impact upon national health care budgets. This proposal requests support for three biannual international meetings on Craniofacial Development and Tissue Regeneration as part of the Gordon Conference Research Series. The significance of this application is that it supports the conference that has become the pre-eminent meeting for the craniofacial community. The broad and long-term goal of these craniofacial GRC meetings is to advance our understanding of the fundamental mechanisms underlying normal craniofacial development, disease and evolution upon which novel avenues for prevention and repair can be developed to manage and treat congenital craniofacial birth defects. The specific aim of this application is to bring together leading investigators to present cutting-edge research on the molecular, cellular and genetic aspects of craniofacial development, evolution, disease and regeneration. More specifically, the Craniofacial GRC meetings will convene approximately 42 speakers representing critical areas of craniofacial development and tissue regeneration. The program will consist of 8 sessions that encompass, neural crest cells and placodes, development of, and interactions between skeletal and connective tissues, signaling pathways mediating cell communication, animal models and genome wide association studies of human disease, advances in regenerative stem cell biology and replacement of craniofacial tissues through tissue engineering. The collegial atmosphere of this Conference together with scheduled opportunities for informal gatherings and poster presentations provides numerous opportunities for interactive discussion, which focuses the field on the many unanswered questions and challenges within craniofacial biology. This proposal addresses a number of the missions and aims of the National Institute for Dental and Craniofacial Research's strategic plan by promoting novel and innovative research avenues for improving critical health issues in craniofacial development as well as preventing congenital craniofacial malformation syndromes. PUBLIC HEALTH RELEVANCE: Head and facial abnormalities account for approximately one third of all birth defects in new born babies, are a major cause of infant mortality and dramatically impact upon national health care budgets. Comprehensive and well-coordinated treatments can provide satisfactory management of each head and facial birth defect. However, the results are rarely fully corrective. Hence considerable effort needs to be invested into developing therapeutic avenues of prevention and also developing better regenerative strategies for craniofacial tissue repair.