Meningioma: Risk Factors and Quality of Life

描述(申请人提供)：在美国国内还没有大规模研究对颅内脑膜瘤的流行病学进行任何方面的研究，脑膜瘤占所有原发颅内肿瘤的25%。我们建议在康涅狄格州、马萨诸塞州、北卡罗来纳州、德克萨斯州以及旧金山湾区的综合R01机制下进行一项基于人群的脑膜瘤病例/对照研究(请注意，所有五个地点都提交了相同的申请)。将使用快速病例确定方法选择病例，将包括上述地区所有男性；以及在2006年7月1日至2010年6月30日期间被诊断患有组织学确诊的20岁至79岁颅内脑膜瘤的女性个人。对照受试者将通过随机数字拨号方法识别，并按性别、种族、地理位置和五岁年龄类别与病例匹配。研究对象将接受电话问卷调查，以收集有关两种主要风险类别的信息，即暴露在电离辐射和激素中，以及其他风险因素，如脑膜瘤和其他肿瘤的家族史、手机使用情况、头部创伤以及有关结局和生活质量的问题。对于病例受试者，将获得石蜡包埋的肿瘤组织块，以允许1)统一的组织学检查，以及2)雌激素、孕激素、雄激素和MIB-1受体的免疫组织化学测试。血液或口腔样本将从所有研究对象中收集，用于检测DNA修复和细胞周期基因的DNA多态。这项研究是首次集中研究脑膜瘤的环境和遗传风险因素。

DESCRIPTION (provided by applicant): No large-scale study within the United States has examined any aspect of the epidemiology of intracranial meningiomas, a lesion which accounts for up to 25% of all primary intracranial neoplasms. We propose to conduct a population-based case/control study of meningioma within the states of Connecticut, Massachusetts, North Carolina, and Texas as well as the San Francisco Bay area under the mechanism of an integrated R01 (Note that identical applications are submitted for all five sites). Cases will be selected using rapid case ascertainment and will include all male; and female individuals diagnosed with a histologically confirmed intra-cranial meningioma between the ages of 20 and 79 years from 7/1/2006 through 6/30/2010 in the above listed regions. Control subjects will be identified via random-digit dial methods and matched to the cases by sex, ethnicity, geographic location, and five-year age category. Study subjects will be administered a telephone questionnaire to collect information on the two primary categories of risk, exposure to ionizing radiation and hormones as well as additional risk factors such as family history of meningioma and other tumors, cell-phone utilization, and head trauma as well as questions on outcome and quality of life. Parraffin-embedded tumor tissue blocks will be obtained for case subjects to allow for 1) a uniform histological review, and 2) immunohistochemical testing for estrogen, progesterone, androgen and MIB-1 receptors. Blood or buccal specimens will be collected from all study subjects for testing of DNA polymorphisms in DNA repair and cell cycle genes. This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma.