Molecular Genetics and Nutrigenomics

摘要 营养基因组学是一个迅速崛起的领域，研究营养物质和蛋白质之间的相互作用。 基因组学。营养基因组学研究试图将影响营养的过程联系起来。 代谢到特定基因，或替代地，识别与特定基因相关的特定基因 与营养相关的终点，然后评估其与营养代谢的关系。真知灼见 源自营养基因组学将构成个性化营养方法的基础，或 “个性化的营养” 分子遗传学和营养基因组学(MGN)核心的目的是提供 为基础科学和临床研究人员提供的服务和支持将增强我们的 了解营养代谢的分子和遗传学基础以及慢性心脏病的风险 衰老过程中的疾病。阐明营养相关疾病的遗传基础和 特征可能提供关键的机械性见解，可能导致更有效的预防和 对这些常见疾病的治疗。为了实现这些目标，MGN核心将提供 向大西洋中部NORC成员提供分子遗传学、基因组学和遗传学方面的服务 流行病学。此外，该核心还将向NORC提供指导和技术支持 用户。 MGN核心将在以下领域提供服务：(1)分子遗传学 (2)分子基因组学(High 通过SNP基因分型和数据处理)；(3)和遗传流行病学(研究设计， 功率计算、链接和关联研究的分析、生物信息学支持 全球气候变化研究和数据挖掘)。 MGN核心旨在通过以下方式补充其他核心中提供的服务 为中心研究人员提供专业知识和支持，以开展基因和基因组研究 肥胖和其他与营养相关的慢性疾病，可以转化为临床研究，以 在CTR核心的支持下评估基因与环境的相互作用，并通过 在支持下评估分子和细胞水平机制的基本机制研究 反弹道导弹核心。过去五年MGN核心的广泛使用和生产力 展示了它为正在进行的研究提供的丰富，通过为中心调查人员提供 随时可以获得广泛的服务，促进 中心调查人员，以及教育学生、研究员和初级教职员工。

Abstract Nutrigenomics is a rapidly emerging field that studies the interface between nutrients and genomics. The study of nutrigenomics attempts to relate the processes affecting nutrient metabolism to particular genes or alternatively, to identify specific genes associated with a nutrition-related endpoint and then assess how its relation to nutrient metabolism. Insights derived from nutrigenomics will form the basis of individualized approaches to nutrition, or 'personalized nutrition.' The purpose of the Molecular Genetics and Nutrigenomics (MGN) Core is to provide services and support for basic science and clinical investigators that will enhance our understanding of the molecular and genetic basis of nutrient metabolism and the risk of chronic disease during aging. Elucidation of the genetic underpinnings of nutrition-related diseases and traits may provide key mechanistic insights that may lead to more effective prevention and treatment for these common diseases. To achieve these goals, the MGN Core will provide services to members of the Mid-Atlantic NORC in molecular genetics, genomics, and genetic epidemiology. Additionally, the Core will provide instruction and technical support to NORC users. The services to be provided by the MGN Core wil be in the areas of: (1) molecular genetics (DNA extraction, genotyping, sequencing, mutation detection); (2) molecular genomics (high through SNP genotyping and data processing); (3) and genetic epidemiology (study design, power calcuations, analysis for linkage and association studies, bioinformatics support for GWAS studies, and data mining). The MGN Core was designed to complement services available in other Cores by providing expertise and support to Center investigators to carry out genetic and genomic studies of obesity and other nutrition-related chronic diseases that can be translated into clinical studies to assess gene by environment interactions with support from the CTR Core, and pursued through basic mechanism studies to assess molecular and cellular level mechanisms with support from the ABBM Core. The extensive use and productivity of the MGN Core in the last five years demonstrates the enrichment it provides to ongoing studies by providing Center investigators with ready access to a wide range of services, promoting cross-disciplinary interactions among Center investigators, and educating students, fellows and junior faculty.