Systems Biology and Connective Tissue Disorders

描述（由申请人提供）：最近对马凡综合征（MFS）小鼠模型的研究表明，为这种先天性疾病设计成功的治疗方法需要对细胞外、信号传导和细胞内分子之间的相互作用网络有一个完整和公正的理解。因此，在NIAMS任务领域（皮肤、骨骼和肌肉）对广泛的结缔组织疾病（CTDs）进行系统和多学科检查，应该在加速发现这些疾病的治疗方法方面取得成果。计算系统生物学是一门新兴的强大策略，它与传统的生物化学、细胞和遗传方法相结合，可以揭示新的调控原理。因此，本次会议将汇集细胞外基质生物学、TGF-2信号传导、CTD和系统生物学领域的基础、转化和临床研究人员：评估应用系统生物学方法描述结缔组织基本疾病机制的相关领域的知识现状。2. 探讨将计算模型预测与基于结构的药物设计和针对特定CTDs的高通量小分子筛选相结合的优势和局限性。3. 确定新技术基础设施的需求，支持能够促进基础和临床科学家之间互动、促进跨学科研究和加快转化应用的倡议和资助机会（rfa和pa）。这将是首次尝试整合CTD发病机制、TGF-2基础生物学、小分子治疗学和系统生物学等主题的会议。

DESCRIPTION (provided by applicant): Recent studies of mouse models of Marfan syndrome (MFS) have shown that devising a successful treatment for such a congenital disease requires an integrated and unbiased understanding of the network of reciprocal interactions among extracellular, signaling and intracellular molecules. It follows that a systematic and multidisciplinary examination of a broad range of connective tissue disorders (CTDs) in the NIAMS mission area (skin, bone and muscle) should be fruitful in accelerating discoveries of treatment of these diseases. Computational systems biology is an emerging powerful strategy that, combined with traditional biochemical, cellular and genetic approaches, can reveal novel regulatory principles. The proposed this meeting is therefore to bring together basic, translational and clinical researchers in the areas of extracellular matrix biology, TGF-2 signaling, CTD and systems biology to: 1. Assess the current state of knowledge in the relevant fields for applying systems biology approach to delineate fundamental disease mechanisms of connective tissues. 2. Explore the advantage and limitations of combining computational modeling predictions with structure-based drug design and high-throughput screening of small molecules for targeting specific CTDs. 3. Identify needs in new technical infrastructures, support initiatives and funding opportunities (RFAs and PAs) that can facilitate interactions among basic and clinical scientists, promote interdisciplinary research and expedite translational applications. Such a meeting will be the first to be held that attempts to integrate the themes of CTD pathogenesis, TGF-2 basic biology, small-molecule therapeutics and systems biology. .