Vector Biology Research and Integrated Vector Management For Malaria Control

在美国拉芬的非亚马逊地区成功控制和最终消灭疟疾需要 有效控制作为疟疾媒介的按蚊。本ICEMR的每个国家/地区 Networic、哥伦比亚、危地马拉、巴拿马和秘鲁有一个国家疟疾控制计划(NMCP)， 具有矢量控制功能。然而，由于对按蚊物种的信息不足，其有效性受到限制。 作为疟疾媒介的蚊子，关于人为因素影响的不确定性 环境变化对疟疾寄生虫传播动态的影响，媒介有效工具有限 NMCP的控制和综合病媒管理(IVM)部分发展不完全。 这个项目的目标是解决我们在理解生态、行为、媒介方面的主要差距 潜在的，并控制疟疾媒介，以指导更多的发展和实施 NMCP的有效IVM战略。基于大量的初步数据和团队成员的经验 在ICEMR网络中代表每个国家的学术机构和NMCP，优先考虑 研究重点放在直接影响媒介生物控制未来成功的关键科学问题上 歌剧。 该项目包括3个具体目标：1)研究疟疾寄生虫的生态、行为和传播 疟疾媒介物种确定关键因素的潜力，以促进更有效的靶向媒介 控制，2)确定ICEMR中每个国家的已知和疑似疟疾媒介物种 网络对恶性疟原虫和间日疟原虫的天然媒介能力不同，以及3)评估 新型媒介生物的多国现场试验及非点源杀虫剂的防制效果 控制可增强NMCP能力的产品，以实施有效的媒介IVM策略 控制，与NMCP合作，ICEMR团队将展示研究的跨领域价值 改善非亚马孙地区生态多样化地区病媒控制的成果 五个加强和评价核不扩散方案的中间物质成分的过程。

Successful malaria control and eventual eliminafion in the non-Amazonian region of Lafin America requires effective control of Anopheles mosquitoes that serve as malaria vectors. Each country of this ICEMR networic, Colombia, Guatemala, Panama, and Peru, has a National Malaria Control Program (NMCP) that features vector control. However, effecfiveness is limited by insufficient informafion on species of Anopheles mosquitoes that serve as malaria vectors, uncertainties regarding the impact of anthropogenic environmental changes on the dynamics of malaria parasite transmission, limited effective tools for vector control, and incompletely developed integrated vector management (IVM) components of NMCPs. The goal of this project is to address major gaps in our understanding of the ecology, behavior, vector potenfial, and control of Anopheles malaria vectors to guide the development and implementation of more effective IVM strategies of NMCPs. Based on extensive preliminary data and experience of team members representing academic institufions and NMCPs in each country within this ICEMR network, priorifies for research focus on key scientific questions that have a direct bearing on the future success of vector control operafions. This project includes 3 specific aims: 1) invesfigate the ecology, behavior, and malaria parasite transmission potential of malaria vector species to identify key factors that would facilitate more effective targeted vector control, 2) determine how known and suspected malaria vector species from each country in the ICEMR network differ in their innate vector competence for Plasmodium falciparum and P. vivax, and 3) assess the efficacy of current vector control operafions of NMCPs and conduct mulfi-country field trials of new vector control products that may strengthen capacifies of NMCPs to implement effective IVM strategies for vector control, In partnership with NMCPs, the ICEMR team will demonstrate the translafional value of research outcomes for improving vector control in ecologically diverse areas o f t he non-Amazonian region through an iterafive process of strengthening and evaluating IVM components of NMCPs.