Mega 2: Manipulation Environment for Genetic Analyses

Mega 2，遗传分析的操作环境，是一个独特的计算机程序，用于促进遗传分析。 从作为遗传研究的一部分收集的数据中创建分析就绪的数据集。Mega 2透明 允许用户准确有效地处理基于家族或病例/对照研究的遗传数据。在 除了数据验证检查外，Mega 2还提供分析设置功能， 常用的基因分析程序。它在遗传学研究中发挥了重要作用 世界各地的社区。根据这项提议，我们计划使Mega 2成为一个强大的开源应用程序， 高度增强的功能，同时应用软件工程中的最佳实践来满足这些关键 开源项目的需求：跨操作系统平台的可移植性，随着遗传学需求而发展的能力 研究、广泛的文档、最大化代码重用以及系统测试、调试和 上维护具体来说，我们计划大大提高Mega 2的可用性，数据输入处理能力， 建立目标分析的能力，以及数据统计的图形表示和存储， 诊断和结果。我们还将开发一个应用程序编程接口和改进 文档和教程。Mega 2已被用于加速基因发现研究， 复杂的人类疾病改善这一关键资源将对加快 基因发现过程，这反过来又将减轻由于复杂的遗传疾病的医疗保健负担， 美国和全世界。 相关性：Mega 2被用于复杂人类疾病遗传学的许多不同研究， 研究人员迅速改变文件格式，并准备文件进行统计分析， 准确有效地处理基因数据。因此，Mega 2已经并将继续显着 加速复杂人类疾病易感基因的定位和鉴定。

Mega2, the Manipulation Environment for Genetic Analysis, is a unique computer program for facilitating the creation of analysis-ready datasets from data gathered as part of a genetic study. Mega2 transparently allows users to process genetic data for family-based or case/control studies accurately and efficiently. In addition to data validation checks, Mega2 provides analysis setup capabilities for a broad choice of commonly-used genetic analysis programs. It has served an important role in the genetics research community worldwide. Under this proposal, we plan to make Mega2 a powerful open-source application with highly enhanced capabilities, while applying best practices in software engineering to meet these critical needs of an open-source project: portability across OS platforms, ability to evolve with the needs of genetics research, extensive documentation, maximizing code reuse, as well as systematic testing, debugging and maintenance. Specifically, we plan to significantly improve Mega2's usability, data input handling capabilities, its abilities to set up target analyses, and its graphical presentation and storage of data statistics, diagnostics, and results. We will also develop an Application Programming Interface and improved documentation and tutorials. Mega2 has been used to accelerate gene discovery studies for a large list of complex human diseases. Improving this crucial resource will have a significant impact on speeding up the gene-discovery process, which in turn will ease the healthcare burden due to complex genetic disease in the US and world-wide. Relevance: Mega2 is used in many different studies of the genetics of complex human diseases, enabling researchers to swiftly change file formats and prepare files for statistical analysis and transparently processing genetic data accurately and efficiently. As such, Mega2 has and will continue to markedly accelerate the mapping and identification of susceptibility loci for complex human diseases.