Engineering for Neurologic Rehabilitation

描述（由申请人提供）：这个R24研究资源，称为“神经康复工程”，旨在传播pi在工程和神经科学方面的核心专业知识，以支持美国医疗中心和医院新教师的发展。该项目将建立在pi目前的R24网络支持下建立的核心设施，以及类似的nidrr资助的研究中心，支持中风和其他神经系统疾病的机器人研究。这些核心设施包括：1。神经科学核心：主任是C.J.赫克曼（西北）和乔治·霍恩比（UIC）。Heckman博士领导一个使用电生理、解剖、免疫组织化学和药理学方法处理脊髓损伤动物模型的实验室。该实验室将用于进行人体试验的准备研究。霍恩比博士的核心将促进人类的临床试验。2. 机器人/机械核心：导演是詹姆斯·巴顿和桑德罗·穆萨-伊瓦尔迪。他们将提供一系列不同的机器人和机械系统，用于基础研究、诊断研究，以及测试中风和脊髓损伤的治疗方法。新的机器人系统，如Haptic Master和其他特殊用途的机器人也将用于协作交互。此外，将提供使用“Lokomat”作为诊断和治疗工具的步态研究。3. 信息技术/传感核心：导演：张利群和保罗·博纳托（斯波尔丁）。这个核心设施有能力建立新的电子系统，如最先进的肌电图电极，遥测数据收集系统，以及广泛的建模和仿真设施。4. 建模和仿真核心：Wendy Murray和Yasin Daher。这些研究核心的可用性将通过专门的网站传播，并在国家和国际会议上提出。最后，将提供一系列的教学课程，实践研讨会和专题讨论会，以介绍新的研究方法。

DESCRIPTION (provided by applicant): This R24 research resource, called "Engineering for Neurological Rehabilitation" seeks to disseminate the PIs' core expertise in engineering and neuroscience to support the development of new faculty in medical centers and hospitals across the United States. This program will build on core facilities established under the auspices of the PIs' current R24 network and under analogous, NIDRR-sponsored research centers supporting robotics research for stroke and other neurological disorders. These core facilities include the following: 1. Neurosciences Core: Directors are C.J. Heckman (Northwestern) and George Hornby (UIC). Dr. Heckman directs a laboratory dealing with animal models of spinal cord injury using electrophysiological, anatomical, immunohistochemical, and pharmacological approaches. This laboratory will be available to pursue studies preparatory to human testing. Dr. Hornby's core will facilitate clinical testing in human populations. 2. Robotics/Mechanics Core: Directors are James Patton and Sandro Mussa-lvaldi. They will make available an array of different robotic and mechanical systems designed for fundamental research, for diagnostic studies, and for testing therapeutic approaches in stroke and spinal cord injury. New robotic systems such as the Haptic Master and other special-purpose robots will also be made available for collaborative interaction. In addition, gait studies using the "Lokomat" as both a diagnostic and therapeutic tool will be offered. 3. Information Technology/Sensing Core: Directors are Li-Qun Zhang and Paolo Bonato (Spaulding). This core facility has the capacity to build novel electronic systems such as state-of-the-art EMG electrodes, telemetered data collection systems, and extensive modeling and simulation facilities. 4. Modeling and Simulation Core: Wendy Murray and Yasin Daher. Availability of these research cores will be disseminated through dedicated websites and presented at national and international meetings. Finally, a series of didactic courses, hands-on workshops, and symposia will be offered to present novel research approaches. PUBLIC HEALTH RELEVANCE: This R24 research resource application seeks to build on expertise in neuroscience and engineering that is concentrated in the research laboratories of the Rehabilitation Institute of Chicago, and in affiliated laboratories at Northwestern University. The PIs offer opportunities for collaboration on studies relating to neurological disorders in animal models, and in human populations.