FASEB SRC on Protein Lipidation, Signaling and Membrane Domains

描述(申请人提供)：蛋白质脂化、信号和膜域领域是一个非常活跃的研究领域，因为研究人员试图完善和扩大我们对蛋白质-脂质相互作用对细胞信号、生长和分化、膜合成和运输的影响，以及这些过程在人类疾病中的作用的理解。我们请求部分资金支持美国实验生物学联合会(FASE B)将于2011年7月24-29日在佛蒙特州萨克斯顿河举行的关于“蛋白质脂肪作用、信号和膜域”的会议。这次会议将突出最近的进展，并提供一个就这些主题进行批判性讨论的论坛，并促进从生物物理和生物化学到癌症生物学、遗传学和临床医学等不同领域的研究人员之间的互动、想法分享和合作。脂质修饰的蛋白质、信号和膜结构域代表着不同的研究领域，但这些领域仍然紧密交织在一起。例如，许多脂化蛋白调节膜的合成和囊泡的运输。此外，脂化蛋白质表现出与膜的强烈而动态的相互作用，它们与效应分子和下游信号伙伴的相互作用可以受到穿梭进出膜微域的影响。因此，这些研究领域的研究人员受益于本次会议发起的讨论和协作，并从中找到协同效应。会议的一个同样重要的作用是促进包括研究生和博士后研究员在内的受训人员与这些领域的知名领导人之间有意义的互动。考虑到会议规模很小(最多200人)，而且要求发言者在整个会议期间一直在现场，这一目标是现实的。我们也致力于促进学员的职业发展。为此，从提交的摘要中选出的发言者将发表17次简短的演讲，其中至少三分之二是从这组人中挑选出来的。此外，我们建议向高素质的研究生和博士后研究员提供25个500美元的旅行奖励，并让他们每个人都有机会在第一个海报会议期间用5分钟的口头陈述总结他们海报中所展示的工作的基本原理、结果和重要性。在遴选过程中，我们将确保各届会议在吸纳妇女和代表性不足的少数群体方面保持平衡。 与公共卫生相关：我们请求部分支持我们将于2011年7月24-29日在佛蒙特州萨克斯顿河举行的题为“蛋白质脂肪作用、信号和膜域”的科学会议。这些研究领域已经成为基础细胞生物学和包括癌症在内的许多人类疾病研究的重要和综合方面。至关重要的是，将这些领域的研究人员聚集在一起，分享发现，交流想法，并发起合作，以便更好地了解这些细胞过程的生物学，并开发针对癌症等疾病的有效治疗方法。

DESCRIPTION (provided by applicant): The field of protein lipidation, signaling and membrane domains is an extremely active area of research as investigators seek to refine and expand our understanding of the consequences of protein-lipid interactions for cell signaling, growth and differentiation, and membrane synthesis and trafficking, and the role of these processes in human disease. We request funds to partially support the Federation of American Societies of Experimental Biology (FASEB) conference on "Protein Lipidation, Signaling and Membrane Domains", that will be held from July 24-29, 2011 in Saxtons River, Vermont. This meeting will highlight recent progress and provide a forum for critical discussions on these topics and promote interactions, idea-sharing, and collaborations between researchers from diverse fields ranging from biophysics and biochemistry to cancer biology, genetics, and clinical medicine. Lipid-modified proteins, signaling, and membrane domains represent distinct areas of research that are nonetheless closely intertwined. For example, many lipidated proteins regulate membrane synthesis and vesicular trafficking. Moreover, lipidated proteins exhibit a strong yet dynamic interaction with membranes and their interaction with effector molecules and downstream signaling partners can be affected by shuttling in and out of membrane microdomains. Thus, investigators in these research areas benefit from and find synergy in discussions and collaborations initiated at this meeting. An equally important function of the meeting is to stimulate meaningful interactions between trainees including graduate students and postdoctoral fellows and established leaders in these fields. This objective is realistic given the small size of the conference (maximum 200 participants) and the requirement that speakers remain on-site throughout the meeting. We are also committed to fostering the career development of trainees. To this end, speakers chosen from submitted abstracts will present seventeen short talks, with at least two-thirds selected from this cohort. Furthermore, we propose to offer 25 travel awards of $500 to highly qualified graduate students and postdoctoral fellows and give them each the opportunity to summarize the rationale, results, and importance of the work presented in their poster in a 5-minute oral presentation during the first poster session. In the selection process, we will ensure that the sessions are balanced with regard to the inclusion of women and underrepresented minority groups. PUBLIC HEALTH RELEVANCE: We are requesting partial support for our scientific conference entitled "Protein Lipidation, Signaling and Membrane Domains", that will be held from July 24-29, 2011 in Saxtons River, Vermont. These research fields have emerged as important and integrated facets in the study of basic cellular biology and many human diseases, including cancer. It is essential to bring together researchers from these fields to share findings, exchange ideas, and initiate collaborations in order to better understand the biology of these cellular processes and develop effective treatments for diseases such as cancer.