4th NY Skeletal Biology and Medicine Conference

描述（由申请人提供）：2011年纽约骨骼生物学与医学（NYSBM）会议是2005年开始的一系列两年一次会议中的第四次国际会议，最初由纽约科学院和西奈山医学院联合主办。本次会议的目标受众包括基础科学家、临床研究人员和临床医生，他们对内分泌学、生理学、细胞生物学、病理学、遗传学、分子生物学、风湿病学、放射学、骨科和肿瘤学等不同学科感兴趣，因为它们与骨骼发育、体内平衡和健康有关。以前的会议有多达250名与会者，其中多达85名在基础和临床骨病各个领域的专家被邀请发言或主持会议。历年来的会议深受世界各地与会者的珍视。在2009年的其他全体会议演讲中，包括杜克大学的赵维卓博士的黛安·沃尔夫纪念就职演讲，剑桥大学的迈克尔·贝里奇爵士的第二场罗莎琳·耶洛演讲，以及哈佛大学的罗兰·巴伦的第二场吉迪恩·罗丹纪念演讲。这次会议现在被认为是骨骼生物学的首要参考会议。它为骨发育和重建的机制提供了重要的见解，包括细胞和机械触发，受体和信号通路。它还涉及到其他生理系统或疾病状态，如免疫系统、炎症、糖尿病、感染和癌症在肌肉骨骼健康中所起的重要作用。最近的研究结果也塑造了治疗方向，集中于多种干预模式，包括抗吸收和重要的合成代谢药物。因此，更好地了解骨骼生物学的基本原理、与骨骼疾病相关的病理生理学以及这些疾病的分子和遗传基础，可能会影响我们找到有效治疗方法的能力。2011年NYSMB将在一个论坛上结合基础、临床和转化研究，旨在提供有关骨骼发育及其与骨病及其治疗的关系方面的最新信息。

DESCRIPTION (provided by applicant): The 2011 New York Skeletal Biology and Medicine (NYSBM) conference is the fourth international conference in a series of biennial meetings that began in 2005, initially under the joint auspices of the New York Academy of Sciences and Mount Sinai School of Medicine. The target audience for this conference comprises of basic scientists, clinical investigators and clinicians with interests in diverse disciplines of endocrinology, physiology, cell biology, pathology, genetics, molecular biology, rheumatology, radiology, orthopedics and oncology as they relate to bone development, homeostasis and health. The previous conferences have had up to 250 participants, of which up to 85 experts in various areas of basic and clinical bone disease were invited to speak or chair sessions. The past years' meetings have been cherished by the participants and attendees from all parts of the world. Featured amongst other plenary lectures in 2009, were the Diane Wolf Memorial Inaugural Lecture given by Dr. Victor Dzau (Duke University), the 2nd Rosalyn Yalow Lecture given by Sir Michael Berridge (University of Cambridge) and the 2nd Gideon Rodan Memorial Lecture given by Roland Baron (Harvard). The conference now commands the reputation as being a premiere reference meeting in skeletal biology. It provides vital insights into the mechanisms of bone development and restructuring, including cellular and mechanical triggers, receptors and signaling pathways. It also touches upon the significant role that other physiological systems or disease states such as the immune system, inflammation, diabetes, infection and cancer play in musculoskeletal health. Recent findings are also shaping therapeutic directions to focus on multiple modes of intervention involving anti-resorptive and importantly anabolic agents. A better understanding of the fundamentals of skeletal biology, the pathophysiology associated with skeletal disease and the molecular and genetic basis of these disorders is thus likely to impact on our ability to find effective treatments. The 2011 NYSMB will combine basic, clinical and translational research in a forum designed to provide the most current information on aspects of skeletal development and its relationship to bone disease and its treatment.