Toll2011 Meeting, Decoding Innate Immunity

描述(申请人提供)：本申请寻求对Toll2011的支持，这是一系列聚焦于天然免疫研究进展的会议中的第四次会议。会议计划于2011年5月4日至7日在意大利里瓦德尔加尔达举行，此前分别在意大利陶尔米纳(2004年)、巴西萨尔瓦多(2006年)和葡萄牙卡斯凯斯/里斯本(2008年)举行了会议。2008年的会议有500多人参加，2011年的最高出席人数将接近600人。这些会议最初非常强调识别微生物成分(来自病毒、细菌、寄生虫、真菌)和通过Toll样受体传递信号，但在后来的几年中，主题已扩大到反映宿主感知病原体的一些新的信号途径(如炎症体激活)。结果在不同的主题，如天然免疫和获得性免疫之间的界面，模型系统，天然免疫的进化和临床研究。许多演讲者来自欧洲、亚洲、美国和美洲其他国家的学术机构，其中包括介绍与先天性免疫相关的治疗学发展的演讲者。会议打算介绍与先天免疫相关的许多方面的尖端科学。 与公共卫生的相关性：关于先天免疫的研究一直在迅速发展，并不断发现新的挑战和发现。Toll2011破译先天免疫会议将把临床医生和科学家聚集在一起，交流、讨论和评估先天免疫领域和相关主题的最新发现。会议将包括以下内容：著名学者在先天性免疫的几个研究方面的讲座，年轻研究人员交流他们的发现的海报会议，以及专家将在听众参与下辩论当天的重要主题的研讨会。本次会议的目标是增进了解，并传播关于了解先天免疫的根本原因的新进展的现有信息。会议还将确定需要回答的重大剩余科学问题，以推进未来对病毒疾病的治疗。

DESCRIPTION (provided by applicant): This application seeks support for Toll2011, the fourth in a series of meetings focused on research advances in innate immunity. The meeting is planned for May 4-7, 2011 in Riva del Garda, Italy and follows meetings in Taormina, Italy (2004), Salvador, Brazil (2006) and Cascais/Lisbon, Portugal (2008). The meeting in 2008 had over 500 participants, and the maximum amount of participants in 2011 will be close to 600. The meetings initially had a strong emphasis on recognition of microbial components (from viruses, bacteria, parasites, fungi) and signaling via Toll-like receptors, but in later years the themes have expanded to reflect a number of new signaling pathways (such as inflammasome activation) in host sensing of pathogens. Results are presented on diverse topics such as the interface between innate and adaptive immunity, model systems, evolution of innate immunity and clinical studies. Many speakers are from academic institutions in Europe, Asia, USA and other countries in the Americas, including speakers presenting on development of therapeutics related to innate immunity. The meeting intends to present cutting-edge science on many aspects related to innate immunity. PUBLIC HEALTH RELEVANCE: The study of innate immunity has been rapidly evolving and new challenges and discoveries are constantly being identified. The Toll2011 Meeting E Decoding innate immunity will bring clinicians and scientists together to exchange, discuss, and evaluate recent discoveries in the field of innate immunity and related topics. The conference will entail the following: lectures from distinguished scholars in several research aspects of innate immunity, poster sessions for young investigators to communicate their findings, and workshops where experts will debate the important topics of the day with audience participation. The goal of this meeting is to enhance understanding and disseminate available information on new developments towards understanding the underlying causes of innate immunity. The conference will also define the significant remaining scientific questions that need to be answered in order to advance future treatments for viral diseases.