Core D: Superfamily/Genome

超级家族/基因组核心(巴比特，董事)在EFI中有三个主要角色：1)它将作为 一个档案资源，维护顺序、结构和功能数据，以支持桥梁项目和科学核心。这与LIMS的不同之处在于，它包括关于EFI超家族所有成员的信息，而不是专注于用于项目跟踪的目标蛋白质集。2)它将对这些超家族进行计算分析，以帮助EFI调查人员进行目标识别、功能预测和验证。3)对于EFI研究人员已经实验确定其功能的酶，它将通过注释转移来注释每个家族中未表征的同源基因。在资源允许的情况下，超家族/基因组核心将开展合作，将我们的分析扩展到其他功能多样化的超家族。

The Superfamily/Genome Core (Babbitt, Director) has three main roles in the EFI: 1) It will serve as an archive resource, maintaining sequence, structural and functional data in support of the Bridging Projects and Scientific Cores. This differs from LIMS in that it includes information about all members of EFI superfamilies rather than focusing on target protein sets for project tracking. 2) It will computationally analyze these superfamilies to aid in target identification, function prediction, and validation by EFI investigators. 3) For enzymes for which the functions have been experimentally established by EFI investigators, it will annotate uncharacterized orthologs in each family by annotation transfer. As resources permit, the Superfamily/Genome Core will develop collaborations to extend our analyses to other functionally diverse superfamilies.