A High Brightness Light Source for UV-VIS Spectroscopic Imaging

描述（由申请人提供）：Energetiq开发了一种用于半导体计量应用的超高亮度光源。同样的基本技术可以广泛应用于生物成像，目前的仪器在光学亮度上是有限的，特别是在紫外光谱区域。该项目名为“用于紫外可见光谱成像的高亮度光源”，其目标是开发一种用于定量紫外可见光谱成像优化的新光源家族。我们的第一阶段计划将(I)为显微镜优化激光驱动等离子体源的原型；（ii）设计与宽带生物显微镜相匹配的波长过滤聚光器系统；然后（iii）开始展示该源在生物细胞成像中的优势。

DESCRIPTION (provided by applicant): Energetiq has developed an ultra-high-brightness light source for semiconductor metrology applications. This same basic technology could have broad application in biological imaging, where today's instruments are limited in optical brightness, particularly in the UV spectral region. The goal of this proposed program, "A High Brightness Light Source for UV-VIS Spectroscopic Imaging" is to develop a new family of light sources optimized for quantitative UV-VIS spectroscopic imaging. Our Phase I program will (i) prototype a laser-driven plasma source optimized for microscopy; (ii) design a wavelength-filtered condenser system matched to a broad-band biological microscope; then (iii) begin to demonstrate the advantages of this source in imaging of biological cells. PUBLIC HEALTH RELEVANCE: Broad-band optical microscopy is a key tool for a wide range of biological studies. However today's instruments are limited, both generally in optical brightness and in particular in the deep UV region, where high-resolution imaging spectrophotometry shows the most potential value. The goal of this proposed program, "A High Brightness Light Source for UV-VIS Spectroscopic Imaging" is to develop a new family of light sources optimized for quantitative UV-VIS spectroscopic imaging. Improved throughput and information content for biological assay is central to the productivity both of medical research and drug development.