Detection System for Refractive Surgery in Donor Eyes Phase II

描述（由申请人提供）：Vision Optimization正在提交一份II期SBIR，以开发和验证一种简单、快速、可靠和敏感的软件检测工具，该工具基于角膜地形，将识别以前接受过激光屈光手术的人类供体眼睛。该技术必须是非侵入性的，并且不需要过度地操作眼球。此外，它必须能够“在现场”，在捐赠者床边获得，因为在美国大约有一半的眼睛是作为角膜-巩膜边缘原位切除的，而不是整个眼球。角膜地形学目前由许多用于形状分析的技术和表面表示组成，包括基于表面高度的系统，以及基于斜率的曲率系统。我们的系统利用独特的硬件系统结合新颖的软件算法来检测供体眼睛屈光手术的存在。在第一阶段工作成功的基础上，第二阶段将寻求通过对作为赠款一部分收集的一系列捐赠者眼睛的研究来验证该软件的前瞻性。此外，在第二阶段，将探索使用其他分类方法，包括Zernike系数，并与其他方法进行比较。第三阶段的进一步开发将寻求产品的上市和销售准备。公共卫生相关性：Vision Optimization正在提交II期SBIR，以开发和验证一种简单、快速、可靠和敏感的软件检测工具，该工具基于角膜地形，将识别先前进行过激光屈光手术的人类供体眼睛

DESCRIPTION (provided by applicant): Vision Optimization is submitting a Phase II SBIR to develop and validate a simple, rapid, reliable, and sensitive software detection tool, based on corneal topography that will identify human donor eyes that have had previous laser refractive surgery. The technique must be noninvasive and must not require excessive manipulation of the globe. In addition, it must be amenable to acquisition "in the field," at the donor bedside, since approximately half of eyes in the U.S. are excised in situ as corneo-scleral rims, rather than whole globes. Corneal topography currently consists of many technologies and surface representations for shape analysis, including surface height-based systems, as well as slope-based curvature systems. Our system utilizes a unique hardware system in combination with novel software algorithms to detect the presence of refractive surgery in donor eyes. Building on the successes of the Phase I work, Phase II will seek to validate this software prospectively through a study of a series of donor eyes collected as part of the grant. Additionally in Phase II, the use of additional classification methods, including Zernike coefficients with be explored and compared to other approaches. Further development in Phase III will seek preparation of the product for release and sales. PUBLIC HEALTH RELEVANCE: Vision Optimization is submitting a Phase II SBIR to develop and validate a simple, rapid, reliable, and sensitive software detection tool, based on corneal topography that will identify human donor eyes that have had previous laser refractive surgery