Discovery of Natural Products and Natural Product-Like Inhibitors

天然产物-主要由微生物、真菌和无脊椎动物生物合成的小分子-具有多种化学结构，产生广泛的生物活性，并占目前使用的治疗药物的大部分。重点是海洋无脊椎动物，我们已经确定了几类新的海洋天然产物，有效地抑制体外肿瘤细胞生长和HIV-1感染。通过采用不同的，但互补的HIV-1检测，我们证明，mirabamides，糖基化和卤代缩酚肽，抑制HIV-1感染的早期阶段进入，和活性概况的套件缩酚肽提供了新的结构活性关系，这类化合物。

Natural products - small molecules biosynthesized primarily by microorganisms, fungi and invertebrates - are engendered with diverse chemical structures that give rise to a broad range of biological activities and account for the majority of currently used therapeutics. With an emphasis on marine invertebrates, we have identified several classes of novel marine natural products that potently inhibit tumor cell growth in vitro, and HIV-1 infection. By employing distinct but complementary HIV-1 assays, we demonstrated that mirabamides, glycosylated and halogenated depsipeptides, inhibit HIV-1 infection at the early stage of entry, and the activity profiles for the suite of depsipeptides provided new structure activity relationships for this class of compounds.