Joint Initiative in Vaccine Economics, Phase 4

描述（由申请人提供）：随着新疫苗的上市，由于疫苗接种计划的预算限制，疫苗经济学研究的需求将增加。这项研究的目的是为免疫实践咨询委员会（ACIP），CDC和其他州和地方决策者正在考虑的疫苗政策建议提供信息。具体目标：拟议的研究涉及疫苗政策中的关键问题：（1）提高疫苗接种覆盖率的潜在健康和经济效益;（2）疫苗风险-效益权衡的社会价值;以及（3）公众对青少年和成人疫苗接种环境的偏好。研究者和环境：这项申请要求继续支持一项非常成功的合作，即疫苗经济学联合倡议，该倡议现已进入第十个年头。JIVE项目包括在广泛的经济评估和决策科学方法方面具有丰富经验的研究人员，包括成本效益分析，效益成本分析，或有价值评估和联合分析，以及建模方法的相关专业知识。疫苗经济学联合倡议在支持哈佛大学、密歇根大学和疾病控制和预防中心（CDC）的合作研究者之间的合作研究方面有着悠久的历史。创新与研究战略：总体方法是使用经济和决策分析方法提供证据，为疫苗政策决策提供信息。初步研究将通过开发美国疫苗接种经济价值的理论模型和使用动态模拟建模的经验模型来衡量疫苗接种覆盖率变化对健康结果，成本和成本效益的经济价值。我们提出了两个额外的研究主题预计有很高的政策影响：疫苗接种相关的不良事件的风险-效益权衡;成人疫苗接种的障碍和促进因素。所提出的方法借鉴了经济和建模方法，包括动态模拟模型，多标准决策分析，联合分析，尚未广泛应用于疫苗政策问题。研究小组将与疾病预防控制中心的研究人员共同确定与政策相关的主题，并制定适当的研究计划。

DESCRIPTION (provided by applicant): As new vaccines become available, the need for vaccine economics research will increase due to budget constraints for vaccination programs. The objective of this research study is to inform vaccine policy recommendations under consideration by the Advisory Committee for Immunization Practices (ACIP), CDC, and other state and local decision makers. Specific Aims: The proposed research studies addresses key issues in vaccine policy: (1) potential health and economic benefits of improved vaccination coverage; (2) societal values for vaccine risk-benefit tradeoffs; and (3) public preferences for adolescent and adult vaccination settings. Investigators and Environment: This application requests continued support for a highly successful collaboration, the Joint Initiative in Vaccine Economics (JIVE), which is now in its tenth year. The JIVE project includes investigators with broad experience in a wide range of economic evaluation and decision science methods including cost-effectiveness analysis, benefit-cost analysis, contingent valuation, and conjoint analysis, as well as related expertise in modeling methods. The Joint Initiative in Vaccine Economics has a long history of supporting collaborative research among co-investigators at Harvard University, the University of Michigan, and the Centers for Disease Control and Prevention (CDC). Innovation and Research Strategy: The overall approach is to use economic and decision analysis methods to provide evidence to inform vaccine policy decisions. The initial study will measure the economic value of changes in vaccination coverage on health outcomes, costs, and cost-effectiveness, by developing a theoretical model of the economic value of vaccination for the US and an empirical model using dynamic simulation modeling. We propose two additional studies on topics anticipated to have high policy impact: risk- benefit tradeoffs for vaccination-related adverse events; barriers and facilitators to adult vaccination. The proposed methods draw on economic and modeling approaches, including dynamic simulation models, multiple-criteria decision analysis, and conjoint analysis, that have not been widely applied to vaccine policy questions. Jointly with investigators from CDC, the research team will identify topics of policy relevance and develop the appropriate research plan.