Preventing Prematurity and Poor Pregnancy Outcomes Training Grant

描述（由申请人提供）：这项新的T-32申请，“预防早产和不良妊娠结局培训资助”，来自范德比尔特大学医学院新生儿学部/儿科系，旨在为儿科亚专科研究员建立博士后培训计划，研究和职业重点是(a)发育和围产期生物学，(b)出生缺陷的遗传、环境和生化/分子原因，早产及其后遗症和(c)通过转化、流行病学、质量改进和比较有效性研究改善出生结果。该计划的长期目标是培养围产期研究领域的医师科学家和未来的领导者，他们将在职业生涯中做出对出生结果有积极影响的贡献。具体目标是在儿科亚专科奖学金培训的早期确定有前途的学员，并在合格导师的监督下为他们提供强大的跨学科研究经验，并随时获得充足的实验室资源、有不良出生结局风险的母亲和婴儿的人群或数据集。该项目将利用范德比尔特大学庞大的机构资源，包括范德比尔特CTSA，大量的核心设施，公共卫生硕士和临床调查科学硕士，质量学者计划和范德比尔特循证实践中心。鉴于申请者人数众多，我们建议在第二年和第三年每年资助两个职位，并承诺在第四年根据需要提供继续培训的机构资金。一群才华横溢的美国国立卫生研究院资助的研究人员从多个学科中选出，他们具有成功的指导记录，代表了范德比尔特大学独特的研究优势。该方案的结构化研究培训将灌输解决围产期健康结果关键问题所需的技能和知识。有潜力的青年教师被确定为“培训导师”。一个由4名成员组成的指导委员会和一个由发育生物学、围产期健康结果和医生-科学家培训领域的校内外专家组成的6名成员的咨询委员会将为学员的选择和进展以及整个方案的成功提供指导。

DESCRIPTION (provided by applicant): This new T-32 application, "Preventing Prematurity and Poor Pregnancy Outcomes Training Grant", from the Division of Neonatology/Department of Pediatrics at Vanderbilt University School of Medicine is for the establishment of a postdoctoral training program for pediatric subspecialty fellows with a research and career focus in (a) developmental and perinatal biology, (b) genetic, environmental and biochemical/molecular causes of birth defects, preterm birth and its sequelae and (c) improvement in birth outcomes through translational, epidemiological, quality improvement and comparative effectiveness research. The long-term goals of this program are to develop physician-scientists and future leaders in perinatal research who will make career-long contributions that will positively impact birth outcomes. The Specific Aims are to identify promising trainees early in pediatric subspecialty fellowship training and provide them with a robust, interdisciplinary research experience under the supervision of a qualified mentor with ready access to adequate laboratory resources, populations or datasets of mothers and infants at risk of poor birth outcomes. This program will capitalize on the vast institutional resources at Vanderbilt including the Vanderbilt CTSA, a plethora of core facilities, the Masters in Public Health and Masters of Science in Clinical Investigation, the Quality Scholars Program and the Vanderbilt Evidence-based Practice Center. Given the strong applicant pool, we propose to fund two positions per year in each of the 2nd and 3rd years of fellowship training with commitment of institutional funds for continued training in a 4th year when desired. A talented group of NIH-funded investigators with proven track records of successful mentorship have been chosen from across multiple disciplines representing the unique research strengths of Vanderbilt University. The program's structured research training will instill the skills and knowledge required to address critical issues in perinatal health outcomes. Promising junior faculty have been identified as "mentors-in-training". A 4 member steering committee and a 6-member advisory committee of intramural and extramural experts in the fields of developmental biology, perinatal health outcomes and physician-scientist training will provide guidance on trainee selection and progress and overall program success. PUBLIC HEALTH RELEVANCE: This new T-32 grant will provide structured training for pediatric subspecialty physician- scientists planning an academic career with a research focus in the causes of preterm birth and disorders arising in the perinatal and newborn period. This program will augment the strong track record in the Division of Neonatology and other pediatric subspecialties at Vanderbilt in producing a diverse and expertly trained workforce of academic pediatricians and biomedical scientists to assume leadership roles to meet the healthcare needs of our Nation's children. This program will provide training in the research methods necessary to address important perinatal health issues and the skills required to successfully engage populations of women and infants in research that will ultimate result in the timely translation of fundamental knowledge into meaningful improvements in birth outcomes.