Laboratory Testing Services

寻找抗癌和艾滋病活性药物的一部分工作包括体内试验。美国国家癌症研究所（NCI）维持动物生产计划，以提供这种体内试验所需的必要实验动物。大部分测试是在近亲繁殖的实验动物中进行的，例如动物生产计划合同殖民地生产的动物。因此，遗传监测合同被用来确定动物生产计划近亲繁殖的啮齿动物群体的遗传纯度。NCI动物生产计划遗传状况的确认和验证是这项工作的主要目标。这项工作是通过利用基于dna的方法来确定遗传纯度以及生化标记和皮肤移植的备用方法来完成的。

A part of the search for active agents against Cancer and AIDS involves in vivo testing. The National Cancer Institute (NCI) maintains the Animal Production Program to supply the necessary laboratory animals needed for this in vivo testing. Much of the testing is performed in inbred laboratory animals such as the ones produced by the Animal Production Program contract colonies. Thus, a genetic monitoring contract is used to determine the genetic purity of the Animal Production Program inbred rodent colonies. The validation and verification of the genetic status of the NCI Animal Production Program is the primary objective of this effort. This effort is accomplished by utilizing DNA-based methods to determine genetic purity along with backup methods of biochemical markers and skin grafts.