NHGRI/DIR Scientific Computing

NHGRI校内研究部为专业研究计算维护了强大的计算基础设施。这些资源用于支持该部门的基因组，生物信息学，临床和行为研究的广泛计划，旨在将基因组和遗传研究转化为对人类遗传疾病的更好理解，以及开发更好的检测，预防和治疗遗传性疾病的方法。 NHGRI/NHGRI维护了几个高端计算机系统，以支持最先进的计算序列分析，结构分析和类似的内存密集型科学计算。该司还提供重要的计算资源，以支持其在全基因组测序、全基因组关联研究和类似类型的全基因组分析方面的高通量研究工作。在过去的一年里，我们特别强调了存储和分析“下一代”测序数据所需的基础设施。这些方法在一次运行中会生成大量数据（数量级为TB），因此需要强大的数据库解决方案、创新的存储和归档策略以及可靠的高性能计算环境。 NHGRI/PNAS拥有一套广泛的商业和公共领域软件，用于处理NHGRI调查人员的各种需求。该列表包括用于DNA和蛋白质序列分析、分子建模、微阵列分析、途径分析、生物统计学以及全基因组关联研究所产生的数据分析的软件。此外，意识到为NHGRI科学家提供一流的临床研究数据库的重要性，一个基于Web和符合HIPAA的数据库，集成了谱系查看器和SQL查询工具，可供所有NHGRI研究人员进行旨在了解各种人类遗传疾病的潜在机制的临床协议。该临床数据库功能允许从NIH临床中心的临床研究信息系统（CRIS）数据库自动导入临床实验室数据。

The NHGRI Division of Intramural Research maintains a robust computational infrastructure for specialized research computing. These resources are provided to support the Division's broad program of genomic, bioinformatic, clinical, and behavioral research aimed at translating genomic and genetic research into a greater understanding of human genetic disease, as well as towards developing better methods for the detection, prevention and treatment of heritable and genetic disorders. NHGRI/DIR maintains several high-end computer systems to support state-of-the-art computational sequence analysis, structure analysis, and similar memory-intensive scientific computing. The Division also provides significant computational resources in support of its high-throughput research efforts in whole-genome sequencing, whole-genome association studies, and similar types of genome-wide analyses. In the last year, we have placed particular emphasis on the infrastructure required to store and analyze "next-generation" sequencing data. These approaches generate enormous amounts of data (on the order of terabytes) in a single run, thereby requiring strong database solutions, innovative storage and archiving strategies, and a reliable high-performance computing environment. NHGRI/DIR maintains an extensive suite of commercial and public domain software for handling the wide range of needs of NHGRI investigators. The list includes software for DNA and protein sequence analysis, molecular modeling, microarray analysis, pathway analysis, biostatistics, and the analysis of data being generated by whole-genome association studies. In addition, realizing the importance of providing NHGRI scientists with a first-rate database for clinical research, a Web-based and HIPAA-compliant database with an integrated pedigree viewer and SQL querying tool is made available to all NHGRI investigators conducting clinical protocols aimed at understanding the underlying mechanisms of a wide variety of human genetic disorders. This clinical databases functionality allows for the automated import of clinical laboratory data from the NIH Clinical Center's Clinical Research Information System (CRIS) database.