TAS::75 0888::TAS BIOMEDICAL (APPLIED/EXPLORATORY)

髋关节骨关节炎是中老年人残疾的主要原因。在膝关节之后，它是关节置换手术最常见的原因。尽管有这种影响，但已确定的髋关节OA发生和进展的风险因素相对较少，并且可能改变的风险因素也较少。已知髋臼和股骨近端的严重发育异常在相对年轻的年龄时具有发生髋关节OA和关节衰竭的高风险。越来越多的证据表明，髋臼和股骨近端形态的更细微变化，包括轻度发育异常，会增加以后患髋关节OA的风险。最近的骨科研究集中在改变髋关节力学和关节表面应力的髋关节形态变化，特别是与股骨髋臼撞击有关的变化。据推测，这些是重要的，但以前未被认识到的风险因素，可能占很大比例的髋关节OA发生在中年和晚年。其中一些髋关节形态学变异可以通过手术干预进行改变，并且对早期治疗以预防后期OA的兴趣越来越大。到目前为止，还没有大型前瞻性队列研究全面测试这些变化，单独或组合，是否与放射学髋关节OA（RHOA）的发展和进展的风险。骨关节炎倡议（OAI）是众所周知的公共访问研究数据库，来自膝关节OA发病率和进展的生物标志物（MRI、生化、遗传）的最大前瞻性研究。鲜为人知的是，OAI也是一项髋关节OA的前瞻性研究。在整个队列的4796名参与者中，在基线时和计划参加4年随访门诊访视的80%的受试者中获得骨盆X线片。我们建议使用经验证的评分系统和测量方法评估OAI骨盆X线片的流行性、进展性和偶发性RHOA，并通过OAI公共网站快速发布这些读数的结果，从而使髋关节OA的存在和结局纳入使用OAI队列的生物标志物研究成为可能。我们还建议对基线骨盆X线片进行全面评估，以测量髋关节形态学，假设髋关节形态学在髋关节OA的发展中起作用，并在这个大型的、特征明确的队列中测试这些测量作为偶发和进展性RHOA的风险因素的影响。还将在随访图像上测量髋关节形态，以研究这些参数作为RHOA的成像生物标志物相对于基线的变化

Hip osteoarthritis is a major cause of disability in middle aged and older persons. After the knee, it is the most common reason for joint replacement surgery. Despite this impact, relatively few risk factors, and fewer still potentially modifiable ones, for hip OA development and progression have been identified. Severe developmental abnormalities of the acetabulum and proximal femur are known to confer a high risk for developing hip OA and joint failure at a relatively young age. There is increasing evidence that more subtle variation in the morphology of the acetabulum and proximal femur, including mild forms of developmental abnormalities, increase the risk of hip OA later in life. Recent orthopedic research has focused on variations of hip morphology that alter hip joint mechanics and joint surface stress, in particular those related to femoro-acetabular impingement. It is hypothesized that these are important, but previously unrecognized, risk factors that may account for a large proportion of hip OA occurrence in mid and late life. Some of these hip morphological variations are modifiable through surgical interventions, and there is increasing interest in early treatment to prevent later OA. To date, no large prospective cohort studies have comprehensively tested whether these variations, alone or in combination, are related to the risk of development and progression of radiographic hip OA (RHOA). The Osteoarthritis Initiative (OAI) is well known as a public access research database from the largest prospective study of biomarkers (MRI, biochemical, genetic) of knee OA incidence and progression. It is less well known that the OAI is also a prospective study of hip OA. Pelvic radiographs were obtained in the entire cohort of 4796 participants at baseline and in the 80% of subjects projected to attend the 4-year follow-up clinic visits. We propose to assess the OAI pelvic radiographs for prevalent, progressive and incident RHOA using validated scoring systems and measurements and to rapidly release the results of these readings through the OAI public web site, thus making it possible for hip OA presence and outcomes to be included in biomarker studies using the OAI cohort. We also propose to comprehensively assess the baseline pelvic radiographs for measures of hip morphology hypothesized to play a role in the development of hip OA, and to test the effect of these measures as risk factors for incident and progressive RHOA in this large, well-characterized cohort. Hip morphology will also be measured on follow-up images to allow investigation of change from baseline in these parameters as imaging biomarkers of RHOA