RGR-based motion tracking for real-time adaptive MR imaging and spectroscopy

描述（由申请人提供）：这是1R01 DA21146-01的续期申请，生物工程研究合作伙伴关系（BRP）开发MRI实时前瞻性运动校正（PMC）。磁共振成像（MRI）是一种强大的技术，用于评估人类大脑的结构、功能和生理。MRI具有高空间和时间分辨率，无创性和可重复性，可用于儿童。然而，在许多磁共振研究中，运动仍然是一个实质性的问题，特别是在儿童，婴儿或因焦虑，吸毒或疾病而激动或困惑的受试者中进行的研究，导致运动伪影的数据可能会妨碍准确的诊断或评估。前瞻性运动校正可以通过在扫描过程中动态跟踪头部/大脑的运动，并不断校正采集结果，使它们相对于运动的大脑被锁定，从而显著减弱运动伪影。在项目初期，我们在开发基于光学的MRI运动跟踪和校正方面取得了实质性进展。虽然最初的原型系统在相对较小和较慢的运动中表现良好，但在临床相关运动（较大振幅和较高速度）中，系统可能无法充分衰减运动伪影。拟议的竞争性更新将侧重于解决这些问题，具体目标如下。(1)提高光学跟踪运动校正的鲁棒性。(2)开发更高速度（高达100mm/s和°/s）的运动校正技术，并将这些方法应用于一组临床相关序列。(3)开发头部运动数据的重建技术。(4)展示所开发的运动矫正方法的临床疗效和实用性。这项工作将由一支经验丰富的调查团队进行，他们使用现代化的3T和7T扫描仪进行合作。实施这些创新将增加临床领域自适应运动校正技术的可用性，并有望在研究和临床环境中对难以保持静止的儿童和患者进行改进和更强大的MR扫描。

DESCRIPTION (provided by applicant): This is a renewal application for 1R01 DA21146-01, a Bioengineering Research Partnership (BRP) to develop real-time prospective motion correction (PMC) for MRI. Magnetic resonance imaging (MRI) is a powerful technique for assessing the structure, function, and physiology of the human brain in vivo. MRI affords high spatial and temporal resolution, is non-invasive and repeatable, and may be performed in children. However, motion continues to be a substantial problem in many MR studies, especially those performed in children, infants, or subjects who are agitated or confused due to anxiety, drug use or sickness, resulting in data with motion artifacts that may prevent accurate diagnoses or assessments. Prospective motion correction can dramatically attenuate motion artifacts by dynamically tracking the motion of the head/brain during a scan, and continuously correcting acquisitions such that they are locked relative to the moving brain. In the initial project period, we made substantial progress in developing optical-based motion tracking and correction for MRI. While the initial prototype system performs well for relatively small and slow movements, the system may fail to sufficiently attenuate motion artifacts during clinically relevant motions (larger amplitudes and higher speed). The proposed competitive renewal will focus on resolving these issues, with the following specific Aims. (1) Improve robustness of motion correction with optical tracking. (2) Develop techniques for motion correction at higher velocities (up to 100mm/s and °/s), and implement these methods for a set of clinically relevant sequences. (3) Develop reconstruction techniques for data acquired during head motion. (4) Demonstrate clinical efficacy and utility of the motion correction methods developed. The work will be performed by an experienced team of investigators with a track record of collaboration, using modern 3T and 7T scanners. Implementing these innovations will increase the availability of adaptive motion correction technologies for the clinical arena, and promise improved and more robust MR scans in children and patients who have difficulty holding still, both in research and clinical settings.